Surgery Today

, Volume 44, Issue 2, pp 285–290 | Cite as

Inhaled tiotropium to prevent postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery

  • Takashi Nojiri
  • Masayoshi Inoue
  • Kazuhiro Yamamoto
  • Hajime Maeda
  • Yukiyasu Takeuchi
  • Tomoyuki Nakagiri
  • Yasushi Shintani
  • Masato Minami
  • Noriyoshi Sawabata
  • Meinoshin Okumura
Original Article



A new diagnosis of chronic obstructive pulmonary disease is often made during the evaluation of patients requiring lung cancer surgery. The objective of the present study was to evaluate the clinical effects of inhaled tiotropium on the postoperative cardiopulmonary complications in patients with untreated chronic obstructive pulmonary disease requiring lung cancer surgery.


A retrospective study involving 104 consecutive patients with moderate to severe chronic obstructive pulmonary disease who underwent a lobectomy for lung cancer at two specialized thoracic centers between April 2008 and October 2011 was performed. The results were compared between patients who did and did not receive inhaled tiotropium during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. The postoperative white blood cell counts and C-reactive protein levels as biomarkers of inflammation were also examined.


The incidence of postoperative cardiopulmonary complications was significantly lower in the tiotropium group than in the control group (18 vs. 48 %, P = 0.001). Patients in the tiotropium group also showed significantly lower white blood cell counts and C-reactive protein levels postoperatively.


Inhaled tiotropium treatment during the perioperative period had a prophylactic effect on postoperative cardiopulmonary complications in patients with newly diagnosed chronic obstructive pulmonary disease requiring lung cancer surgery.


Lung cancer surgery Perioperative care Surgery Complications 


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Takashi Nojiri
    • 1
    • 2
  • Masayoshi Inoue
    • 1
  • Kazuhiro Yamamoto
    • 3
  • Hajime Maeda
    • 2
  • Yukiyasu Takeuchi
    • 2
  • Tomoyuki Nakagiri
    • 1
  • Yasushi Shintani
    • 1
  • Masato Minami
    • 1
  • Noriyoshi Sawabata
    • 1
  • Meinoshin Okumura
    • 1
  1. 1.Department of General Thoracic SurgeryOsaka University Graduate School of MedicineSuitaJapan
  2. 2.Department of General Thoracic SurgeryNational Hospital Organization Toneyama HospitalToyonakaJapan
  3. 3.Department of Molecular Medicine and Therapeutics Faculty of MedicineTottori University HospitalYonagoJapan

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