Surgery Today

, Volume 43, Issue 6, pp 648–653 | Cite as

Intrapleural chemotherapy improves the survival of non-small cell lung cancer patients with positive pleural lavage cytology

  • Tetsuro Baba
  • Hidetaka Uramoto
  • Taiji Kuwata
  • Masaru Takenaka
  • Yasuhiro Chikaishi
  • Souichi Oka
  • Yoshika Nagata
  • Yoshiki Shigematsu
  • Hidehiko Shimokawa
  • Makoto Nakagawa
  • Tomoko So
  • Takeshi Hanagiri
  • Fumihiro Tanaka
Original Article

Abstract

Purpose

Information regarding the treatment of pleural lavage cytology (PLC)-positive patients is still limited. This study evaluated the efficacy of intrapleural chemotherapy (IPC) in PLC-positive patients.

Methods

Three hundred eighty-six of the 567 lung cancer patients who underwent surgery had undergone PLC after thoracotomy, following by a complete resection were evaluated. IPC was performed after surgery, and cisplatin or adriamycin was injected intrapleurally through the thoracic tube.

Results

The pathological diagnosis showed that 17 patients (4.4 %) were positive for (or suspected to have) malignancy in their PLC. The univariate and multivariate analysis showed that only pleural invasion was a significant predictor of a PLC-positive status. The 5-year overall survival in PLC-positive patients was 38 % and that in PLC-negative patients was 84 %. Both the univariate (p < 0.01) and multivariate (p = 0.045) analyses showed that the status of PLC was significantly associated with the overall survival. Eight of the 17 PLC-positive patients underwent IPC. The 2-year OS rate in the patients treated with IPC was 88 % and that of those without IPC was 44 (p = 0.04).

Conclusion

IPC improved the postoperative survival in PLC-positive NSCLC patients, and a further prospective evaluation regarding this therapy is warranted.

Keywords

Non-small cell lung cancer Pleural lavage cytology Intrapleural chemotherapy Prognosis 

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Copyright information

© Springer 2012

Authors and Affiliations

  • Tetsuro Baba
    • 1
  • Hidetaka Uramoto
    • 1
  • Taiji Kuwata
    • 1
  • Masaru Takenaka
    • 1
  • Yasuhiro Chikaishi
    • 1
  • Souichi Oka
    • 1
  • Yoshika Nagata
    • 1
  • Yoshiki Shigematsu
    • 1
  • Hidehiko Shimokawa
    • 1
  • Makoto Nakagawa
    • 1
  • Tomoko So
    • 1
  • Takeshi Hanagiri
    • 1
  • Fumihiro Tanaka
    • 1
  1. 1.Second Department of Surgery II, School of Medicine University of Occupational and Environmental HealthKitakyushuJapan

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