Implications of surgical intervention in the treatment of neuroblastomas: 20-year experience of a single institution
- 159 Downloads
The implications of surgical intervention for neuroblastomas were assessed in one institution.
We analyzed the clinical characteristics and extension of resection in 123 pediatric patients with neuroblastoma diagnosed between 1985 and 2004.
The 5-year survival rate of the 82 patients under 12 months of age, 59 of whom were treated with complete resection of the primary tumor, was 97%. The 5-year survival rate of the 41 patients over 12 months of age did not differ significantly according to whether complete (n = 19) or incomplete resection (n = 22) was performed (46 vs. 38%, respectively). No local recurrence was observed in ten patients over 12 months of age with stage 4 disease who underwent complete resection of the primary tumor; however, four of these ten patients died of metastatic recurrence.
Considering that the majority of infantile neuroblastomas in this study had favorable biology, complete resection might be unnecessary for patients under 12 years of age. For advanced neuroblastomas in patients over 12 months of age, the main treatment for metastasis is systemic chemotherapy, although extirpation of the primary tumor without extensive surgery might prevent local recurrence when combined with radiation therapy.
KeywordsNeuroblastoma Surgical intervention Biology
This work was supported in part by a grant-in-aid for scientific research from the Japanese Society for the Promotion of Science.
- 7.Matsumura T, Sawada T, Shikata T. New trend in treatment strategy for neuroblastoma infants in Japan. Proceedings of the 32nd Annual Meeting of American Society of Clinical Oncology. J Clin Oncol. 1996;15:461.Google Scholar