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Surgery Today

, Volume 42, Issue 3, pp 238–244 | Cite as

Clinical implications of the margin cytology findings and margin/tumor size ratio in patients who underwent pulmonary excision for peripheral non-small cell lung cancer

  • Noriyoshi Sawabata
  • Hajime Maeda
  • Akihide Matsumura
  • Mitsunori Ohta
  • Meinoshin Okumura
  • The Thoracic Surgery Study Group of Osaka University
Original Article

Abstract

Purpose

A pulmonary wedge resection is useful for the treatment of peripheral non-small cell lung cancer (NSCLC). The margin/tumor size ratio (M/T) is a predictor of positive margin cytology findings in these procedures, although the long-term clinical implications remain unclear. This relationship was investigated in this study.

Methods

Thirty-seven cases with a high surgical risk without additional pulmonary resection were selected from those accrued in a multicenter prospective study of optimal margin distance for pulmonary excision of peripheral NSCLC and followed for more than 5 years (range 5.3–14 years).

Results

Both the M/T and margin cytology findings were indicators of cancer recurrence and survival. All seven cases of surgical margin recurrence had a cytology-positive surgical margin. The 5-year survival rate was 54.2% (n = 24) for M/T < 1 and 84.6% for M/T ≥ 1 (n = 13, P = 0.05), while it was 38.5% for positive margin (n = 13) and 79.2% for negative margin (n = 24) cases (P = 0.001). In addition, the margin cytology findings were an independent prognostic factor.

Conclusion

A pulmonary wedge resection for peripheral NSCLC should result in a negative malignant margin, which might be obtained from a sufficient tumor margin ratio of M/T ≥ 1.

Keywords

Non-small cell lung cancer Pulmonary excision Margin cytology Margin/tumor ratio Prognosis 

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Copyright information

© Springer 2011

Authors and Affiliations

  • Noriyoshi Sawabata
    • 1
  • Hajime Maeda
    • 1
  • Akihide Matsumura
    • 1
  • Mitsunori Ohta
    • 1
  • Meinoshin Okumura
    • 1
  • The Thoracic Surgery Study Group of Osaka University
  1. 1.Department of General Thoracic SurgeryOsaka University Graduate School of MedicineSuitaJapan

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