Surgery Today

, 41:1325

Liver transplantation for patients with human immunodeficiency virus and hepatitis C virus coinfection with special reference to hemophiliac recipients in Japan

  • Susumu Eguchi
  • Akihiko Soyama
  • Masaaki Hidaka
  • Mitsuhisa Takatsuki
  • Izumi Muraoka
  • Tetsuo Tomonaga
  • Takashi Kanematsu
Review Article

Abstract

Liver transplantation for patients with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) remains challenging. The advent of highly active antiretroviral therapy (HAART) for HIV has reduced mortality from opportunistic infection related to acquired immunodeficiency syndrome dramatically, while about 50% of patients die of end-stage liver cirrhosis resulting from HCV. In Japan, liver cirrhosis frequently develops after HCV-HIV coinfection resulting from previously transfused infected blood products for hemophilia. The problems of liver transplantation for those patients arise from the need to control calcineurin inhibitor with HAART drugs, the difficulty of using interferon after liver transplantation with HAART, and the need to control intraoperative coagulopathy associated with hemophilia. We review published reports of liver transplantation for these patients in the updated world literature.

Key words

Liver transplantation Hepatitis C virus Human immunodeficiency virus Coinfection Highly active antiretroviral therapy 

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Copyright information

© Springer 2011

Authors and Affiliations

  • Susumu Eguchi
    • 1
  • Akihiko Soyama
    • 1
    • 2
  • Masaaki Hidaka
    • 1
  • Mitsuhisa Takatsuki
    • 1
  • Izumi Muraoka
    • 1
  • Tetsuo Tomonaga
    • 1
  • Takashi Kanematsu
    • 1
  1. 1.Department of SurgeryNagasaki University Graduate School of Biomedical SciencesNagasakiJapan
  2. 2.Japan Foundation for AIDS PreventionTokyoJapan

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