Goblet cell carcinoid of the rectum with lymph node metastasis: Report of a case
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We report an unusual case of goblet cell carcinoid (GCC) of the rectum. A 75-year-old man was admitted to our hospital with anal bleeding, and a hard tumor was felt on the anterior wall of the lower rectum during rectal examination. We performed colonoscopy, and found a 30-mm type 2 tumor in the lower rectum and anal canal. Histological examination of biopsies revealed rectal adenocarcinoma. Based on these findings, we diagnosed rectal adenocarcinoma and performed Miles’ operation with lymph node dissection. Histological examination revealed an invasive lesion composed of signet-ring-like cells. Seven regional lymph node metastases were seen microscopically. The tumor produced copious mucin, which was stained with Alcian blue. Immunohistochemistry was positive for synaptophysin, chromogranin A, CD56, carcinoembryonic antigen, p53, Ki-67, E-cadherin, and cytokeratin 20. The final diagnosis was GCC of the rectum.
Key wordsGoblet cell carcinoid Rectum Lymph node metastasis
- 2.Hamilton SR, Aaltonen LA, editors. World Health Organization classification. Tumors of the digestive system. Lyon: IARC Press; 2000. p. 99–101.Google Scholar
- 7.Ishii Y, Wakaki K, Ishizawa S, Kiya C, Saitou K, Sasahara M. Goblet cell carcinoid of the rectum: A case report (in Japanese with English abstract). Nippon Rinsho Saibou Gakkai Zasshi (J Jpn Soc Clin Cytol) 2001;40:616–621.Google Scholar
- 9.Kato H, Hayashi K, Sugihara K, Nemoto A, Fujiwara K, Tohyama T, et al. A case report of ulcerative colitis accompanied by goblet cell carcinoid and adenocarcinoma (in Japanese). Nippon Shokakibyo Gakkai Zasshi (Jpn J Gastroenterol) 2002;99:500–504.Google Scholar