Surgery Today

, 41:881

Pigmented hepatocellular adenoma: Report of a case

  • Toshiro Masuda
  • Toru Beppu
  • Koei Ikeda
  • Takatoshi Ishiko
  • Akira Chikamoto
  • Hiromitsu Hayashi
  • Hirohisa Okabe
  • Ryu Otao
  • Hiroshi Takamori
  • Tomohiro Namimoto
  • Ken-Ichi Iyama
  • Hideo Baba
Case Report

Abstract

Hepatocellular adenoma is a rare, benign neoplasm that is related to the use of contraceptives or androgenicanabolic steroids. A 51-year-old man with no history of steroid use was found to have a liver tumor. Plain computed tomography showed a high-density tumor that was enhanced in the arterial phase, and the enhancement was prolonged in the delayed phase. Magnetic resonance imaging showed that the tumor was hyperintense on in- and opposed-phase T1-weighted gradient recalled echo images and hyperintense on T1-weighted spin echo images. A partial hepatic resection was performed. A histological examination revealed normal hepatocyte-like tumor cells, composed of abundant dark brown granules of Dubin-Johnson-like pigment, which stained positively for Masson-Fontana stain. The tumor was diagnosed to be a very rare hepatocellular adenoma with the deposition of Dubin-Johnson-like pigment.

Keywords

Hepatocellular adenoma Pigment Magnetic resonance imaging 

References

  1. 1.
    Rebouissou S, Bioulac-Sage P, Zucman-Rossi J. Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma. J Hepatol 2008;48(1):163–170.PubMedCrossRefGoogle Scholar
  2. 2.
    Chiche L, Dao T, Salame E, Galais MP, Bouvard N, Schmutz G, et al. Liver adenomatosis: reappraisal, diagnosis, and surgical management: eight new cases and review of the literature. Ann Surg 2000;231(1):74–81.PubMedCrossRefGoogle Scholar
  3. 3.
    Vetelainen R, Erdogan D, de Graaf W, ten Kate F, Jansen PL, Gouma DJ, et al. Liver adenomatosis: re-evaluation of aetiology and management. Liver Int 2008;28(4):499–508.PubMedCrossRefGoogle Scholar
  4. 4.
    Hasan N, Coutts M, Portmann B. Pigmented liver cell adenoma in two male patients. Am J Surg Pathol 2000;24(10):1429–1432.PubMedCrossRefGoogle Scholar
  5. 5.
    Bernard PH, Blanc JF, Paulusma C, Le Bail B, Carles J, Balabaud C, et al. Multiple black hepatocellular adenomas in a male patient. Eur J Gastroenterol Hepatol 2000;12(11):1253–1257.PubMedCrossRefGoogle Scholar
  6. 6.
    Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A. Hepatic adenomas: imaging and pathologic findings. Radiographics 2001;21(4):877–892; discussion 92–4.PubMedGoogle Scholar

Copyright information

© Springer 2011

Authors and Affiliations

  • Toshiro Masuda
    • 1
  • Toru Beppu
    • 1
  • Koei Ikeda
    • 3
  • Takatoshi Ishiko
    • 1
  • Akira Chikamoto
    • 1
  • Hiromitsu Hayashi
    • 1
  • Hirohisa Okabe
    • 1
  • Ryu Otao
    • 1
  • Hiroshi Takamori
    • 1
  • Tomohiro Namimoto
    • 2
  • Ken-Ichi Iyama
    • 3
  • Hideo Baba
    • 1
  1. 1.Department of Gastroenterological Surgery, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan
  2. 2.Department of Diagnostic Radiology, Graduate School of Medical SciencesKumamoto UniversityKumamotoJapan
  3. 3.Department of Surgical PathologyKumamoto University HospitalKumamotoJapan

Personalised recommendations