Surgery Today

, Volume 41, Issue 3, pp 430–435

Carcinoid tumors of the extrahepatic biliary tract: Report of four cases

  • Jae Hoon Lee
  • Kyeong Geun Lee
  • Young Ha Oh
  • Seung Sam Paik
  • Hwon Kyum Park
  • Kwang Soo Lee
Case Report

Abstract

Carcinoid tumors located in the biliary tree are exceedingly rare, accounting for 0.2%–2% of all gastrointestinal carcinoids. This study describes four cases of carcinoid tumors of the extrahepatic biliary tract. Four carcinoid tumors arising in the common bile duct (Case 1, 59-year-old man), gallbladder (Case 2, 49-year-old man; Case 3, 65-year-old man), and ampulla of Vater (Case 4, 52-year-old woman) were studied. All of the cases were misdiagnosed before surgery as proximal bile duct cancer, stomach cancer with liver metastasis, gallbladder cancer, and adenocarcinoma of ampulla of Vater, respectively. The clinicopathological characteristics and clinical course were reviewed. Treatment depends on the location of the tumor and the extent of the disease. Aggressive surgical therapy with a curative intention therefore offers the only chance for cure and has to be considered whenever possible.

Key words

Carcinoid tumor Common bile duct Gallbladder Ampulla of Vater 

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References

  1. 1.
    Oberndorfer S. Karzenoide Tumoren des Dunndarms. Frankf Zschr Path 1907;1:426–430.Google Scholar
  2. 2.
    Solcia E, Kloppel G, Sobin LH. Histological typing of endocrine tumours. Berlin New York Heidelberg: Springer; 2000.Google Scholar
  3. 3.
    Pilz E. Uber ein karzinoid des ductus choldedochus. Zentralbl Chir 1961;86:1588–1590.PubMedGoogle Scholar
  4. 4.
    Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg 2005;29:92–101.PubMedCrossRefGoogle Scholar
  5. 5.
    Chamberlin RS, Blumgart LH. Carcinoid tumors of the extrahepatic bile duct: a rare cause of malignant biliary obstruction. Cancer 1999;86:1959–1965.CrossRefGoogle Scholar
  6. 6.
    El Rassi ZS, Mohsine RM, Berger F, Thierry P, Partensky CC. Endocrine tumors of the extrahepatic bile ducts. Pathological and clinical aspects, surgical management and outcome. Hepatogastroenterology 2004;51:1295–1300.PubMedGoogle Scholar
  7. 7.
    Gusani NJ, Marsh JW, Nalesnik MA, Tublin ME, Gamblin TC. Carcinoid of the extra-hepatic bile duct: a case report with long-term follow-up and review of literature. Am Surg 2008;74:87–90.PubMedGoogle Scholar
  8. 8.
    Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003;97:934–959.PubMedCrossRefGoogle Scholar
  9. 9.
    Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg 2005;29:92–101.PubMedCrossRefGoogle Scholar
  10. 10.
    Emory RE, Emory TS, Goellner JR, Grant CS, Nagorney DM. Neuroendocrine ampullary tumors: spectrum of disease including the fi rst report of a neuroendocrine carcinoma of non-small cell type. Surgery 1994;115:762–766.PubMedGoogle Scholar
  11. 11.
    Poultsides GA, Frederick WA. Carcinoid of the ampulla of Vater: morphologic features and clinical implications. World J Gastroenterol 2006;12:7058–7060.PubMedGoogle Scholar
  12. 12.
    Henson DE, Albores-Saavedra J, Compton CC. Protocol for the examination of the specimens from patients with carcinomas of the extrahepatic bile ducts, exclusive of the sarcomas and carcinoid tumours: a basis for checklist. Cancer Committee of the College of American Pathologists. Arch Pathol Lab Med 2000;124:26–29.PubMedGoogle Scholar
  13. 13.
    Andreola S, Lombardi L, Audisio RA, Mazzaferro V, Koukouras D, Doci R, et al. A clinicopathologic study of primary hepatic carcinoid tumors. Cancer 1990;65:1211–1218.PubMedCrossRefGoogle Scholar
  14. 14.
    Maitra A, Krueger JE, Tascilar M, Offerhaus GJ, Angeles-Angeles A, Klimstra DS, et al. Carcinoid tumors of the extrahepatic bile ducts: a study of seven cases. Am J Surg Pathol 2000;24:1501–1510.PubMedCrossRefGoogle Scholar
  15. 15.
    Kaiho T, Tanaka T, Tsuchiya S, Miura M, Saigusa N, Yanagisawa S, et al: A case of classical carcinoid tumor of the gallbladder: review of the Japanese published works. Hepatogastroenterology 1999; 46:2189–2195.PubMedGoogle Scholar
  16. 16.
    Hermina M, Starling J, Warner TF. Carcinoid tumor of the cystic duct. Pathol Res Pract 1999;195:707–710.PubMedGoogle Scholar
  17. 17.
    Hatzitheoklitos E, Buchler MW, Friess H, Poch B, Ebert M, Mohr W, et al. Carcinoid of the ampulla of Vater. Clinical characteristics and morphologic features. Cancer 1994;73:1580–1588.PubMedCrossRefGoogle Scholar
  18. 18.
    Marklouf HR, Burke AP, Sobin LH. Carcinoid tumors of the ampulla of Vater: a comparison with duodenal carcinoid tumors. Cancer 1999;85:1241–1249.CrossRefGoogle Scholar
  19. 19.
    Todoroki T, Sano T, Yamada S, Hirahara N, Toda N, Tsukada K, et al. Clear cell carcinoid tumor of the distal common bile duct. World J Surg Oncol 2007;17:5–6.Google Scholar

Copyright information

© Springer 2011

Authors and Affiliations

  • Jae Hoon Lee
    • 1
  • Kyeong Geun Lee
    • 1
  • Young Ha Oh
    • 2
  • Seung Sam Paik
    • 2
  • Hwon Kyum Park
    • 1
  • Kwang Soo Lee
    • 1
  1. 1.Department of Surgery, College of MedicineHanyang UniversitySeoulRepublic of Korea
  2. 2.Department of Pathology, College of MedicineHanyang UniversitySeoulRepublic of Korea

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