Surgery Today

, Volume 40, Issue 10, pp 954–957 | Cite as

Multicenter prospective randomized phase II study of antimicrobial prophylaxis in low-risk patients undergoing colon surgery

  • Junzo Shimizu
  • Kimimasa Ikeda
  • Mutsumi Fukunaga
  • Kohei Murata
  • Atsushi Miyamoto
  • Koji Umeshita
  • Tetsuro Kobayashi
  • Morito Monden
Original Article

Abstract

Purpose

Postoperative antimicrobial therapy is generally administered as standard prophylaxis against postoperative infection, despite a lack of sufficient evidence for its usefulness. This study was a phase II study to evaluate the necessity of postoperative antibiotic prophylaxis in patients undergoing a colectomy.

Methods

Patients received 1 g cefmetazole or flomoxef immediately after anesthetic induction, every 3 h during surgery, and then later once again on the next day. They were randomly assigned to receive either cefmetazole or flomoxef.

Results

Ninety-one patients were enrolled in the study. A surgical site infection (SSI) occurred in 7.7% (7/91) of patients. All cases were superficial incisional infections. When comparing the two drugs, SSI occurred in 8.3% (4/48) of patients treated with cefmetazole and in 7.0% (3/43) treated with flomoxef, showing no significant difference (P > 0.99).

Conclusion

Antimicrobial prophylaxis was well tolerated when used on the day of a colectomy and once again on the next day.

Key words

Antimicrobial prophylaxis Surgical site infection 

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Copyright information

© Springer 2010

Authors and Affiliations

  • Junzo Shimizu
    • 1
    • 7
  • Kimimasa Ikeda
    • 1
  • Mutsumi Fukunaga
    • 2
  • Kohei Murata
    • 3
  • Atsushi Miyamoto
    • 5
    • 7
  • Koji Umeshita
    • 6
    • 7
  • Tetsuro Kobayashi
    • 4
    • 7
  • Morito Monden
    • 6
    • 7
  1. 1.Department of SurgeryToyonaka Municipal HospitalToyonaka, OsakaJapan
  2. 2.Department of SurgerySakai Municipal HospitalSakai, OsakaJapan
  3. 3.Department of SurgerySuita Municipal HospitalSuita, OsakaJapan
  4. 4.Department of SurgeryIkeda Municipal HospitalIkeda, OsakaJapan
  5. 5.Department of SurgeryOsaka National HospitalOsakaJapan
  6. 6.Department of Gastroenterological SurgeryOsaka University Graduate School of MedicineOsakaJapan
  7. 7.Multicenter Clinical Study Group of OsakaRisk Management GroupOsakaJapan

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