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Surgery Today

, Volume 39, Issue 2, pp 133–136 | Cite as

Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: Report of a case

  • Shigeru Miyagawa
  • Goro Matsumiya
  • Toshihiro Funatsu
  • Masao Yoshitatsu
  • Naozumi Sekiya
  • Shinya Fukui
  • Takaya Hoashi
  • Masatsugu Hori
  • Hideki Yoshikawa
  • Yuzuru Kanakura
  • Jun Ishikawa
  • Katsuyuki Aozasa
  • Naomasa Kawaguchi
  • Nariaki Matsuura
  • Akira Myoui
  • Akifumi Matsuyama
  • Sachiko Ezoe
  • Hidehiro Iida
  • Hikaru Matsuda
  • Yoshiki Sawa
Case Report

Abstract

Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.

Key words

Cell transplantation Heart failure Left ventricular assist device 

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References

  1. 1.
    Dib N, Michler RE, Pagani FD, Wright S, Kereiakes DJ, Lengerich R, et al. Safety and feasibility of autologous myoblast transplantation in patients with ischemic cardiomyopathy: four-year followup. Circulation 2005;112(12):1748–1755.PubMedCrossRefGoogle Scholar
  2. 2.
    Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, et al. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 2003;107(18):2294–2302.PubMedCrossRefGoogle Scholar
  3. 3.
    Miyagawa S, Sawa Y, Taketani S, Kawaguchi N, Nakamura T, Matsuura N, et al. Myocardial regeneration therapy for heart failure: hepatocyte growth factor enhances the effect of cellular cardiomyoplasty. Circulation 2002;105(21):2556–2561.PubMedCrossRefGoogle Scholar
  4. 4.
    Memon IA, Sawa Y, Miyagawa S, Taketani S, Matsuda H. Combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells in canine hearts for ischemic cardiomyopathy. J Thorac Cardiovasc Surg 2005;130(3):646–653.PubMedCrossRefGoogle Scholar
  5. 5.
    Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, Masaki H, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: a pilot study and a randomised controlled trial. Lancet 2002;10;360(9331):427–435.PubMedCrossRefGoogle Scholar
  6. 6.
    Ishii K, Miwa K, Makita T, Okuda N. Prolonged postischemic regional left ventricular delayed relaxation or diastolic asynchrony detected by color kinesis following coronary vasospasm. Am J Cardiol 2003;91(11):1366–1369.PubMedCrossRefGoogle Scholar
  7. 7.
    Mancini DM, Beniaminovitz A, Levin H, Catanese K, Flannery M, DiTullio M, et al. Low incidence of myocardial recovery after left ventricular assist device implantation in patients with chronic heart failure. Circulation 1998;98:2383–2389.PubMedGoogle Scholar

Copyright information

© Springer 2009

Authors and Affiliations

  • Shigeru Miyagawa
    • 1
  • Goro Matsumiya
    • 1
  • Toshihiro Funatsu
    • 1
  • Masao Yoshitatsu
    • 1
  • Naozumi Sekiya
    • 1
  • Shinya Fukui
    • 1
  • Takaya Hoashi
    • 1
  • Masatsugu Hori
    • 2
  • Hideki Yoshikawa
    • 3
  • Yuzuru Kanakura
    • 4
  • Jun Ishikawa
    • 4
  • Katsuyuki Aozasa
    • 5
  • Naomasa Kawaguchi
    • 6
  • Nariaki Matsuura
    • 6
  • Akira Myoui
    • 7
  • Akifumi Matsuyama
    • 7
  • Sachiko Ezoe
    • 7
  • Hidehiro Iida
    • 8
  • Hikaru Matsuda
    • 9
  • Yoshiki Sawa
    • 1
  1. 1.Division of Cardiovascular Surgery, Department of SurgeryOsaka University Graduate School of MedicineOsakaJapan
  2. 2.Department of Cardiovascular MedicineOsaka University Graduate School of MedicineOsakaJapan
  3. 3.Department of OrthopedicsOsaka University Graduate School of MedicineOsakaJapan
  4. 4.Department of Hematology and OncologyOsaka University Graduate School of MedicineOsakaJapan
  5. 5.Department of PathologyOsaka University Graduate School of MedicineOsakaJapan
  6. 6.Department of Pathology, School of Allied Health Science, Faculty of MedicineOsaka University Graduate School of MedicineOsakaJapan
  7. 7.Medical Center for Translational ResearchOsaka University Graduate School of MedicineOsakaJapan
  8. 8.Department of Investigative RadiologyNational Cardiovascular Center Research Institute, SuitaOsakaJapan
  9. 9.Department of Cardiovascular SurgeryHyogo Medical College, NishinomiyaHyogoJapan

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