Surgery Today

, Volume 38, Issue 7, pp 635–638 | Cite as

Localized malignant mesothelioma in the middle mediastinum: Report of a case

  • Shintaro Akamoto
  • Yasuhiko Ono
  • Kazumi Ota
  • Norikazu Suzaki
  • Akinori Sasaki
  • Yoshihiro Matsuo
  • Kazuhiko Hayashi
Case Report

Abstract

Localized malignant mesothelioma in the mediastinum is rare and most known cases have been reported as “localized malignant pericardial mesothelioma.” We report a case of a middle mediastinal tumor, which we were able to resect completely. Histopathological examination of the tumor confirmed that it was a malignant epithelial lymphohistiocytoid mesothelioma. We assumed that the tumor was derived from the pericardium. Local recurrence was detected 1 year after resection, and the patient died of the disease about 2 years later.

Key words

Localized malignant mesothelioma Middle mediastinal tumor Lymphohistiocytoid mesothelioma 

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References

  1. 1.
    Burke A, Virmani R. Malignant mesothelioma of the pericardium. In: Rosai J, Sobin LH, editors. Tumors of the heart and great vessels. Atlas of tumor pathology, 3rd series, fascicle 16. Washington, DC: Armed Forces Institute of Pathology; 1996. p. 181–194.Google Scholar
  2. 2.
    Crotty TB, Myers JL, Katzenstein AL, Tazelaar HD, Swensen SJ, Churg A. Localized malignant mesothelioma. A clinicopathologic and flow cytometric study. Am J Surg Pathol 1994;18:357–363.PubMedCrossRefGoogle Scholar
  3. 3.
    Erdogan E, Demirkazik FB, Gulsun M, Ariyurek M, Emri S, Sak SD. Incidental localized (solitary) mediastinal malignant mesothelioma. Br J Radiol 2005;78:858–861.PubMedCrossRefGoogle Scholar
  4. 4.
    Val-Bernal JF, Figols J, Gomez-Roman JJ. Incidental localized (solitary) epithelial mesothelioma of the pericardium: case report and literature review. Cardiovasc Pathol 2002;11:181–185.PubMedCrossRefGoogle Scholar
  5. 5.
    Sane AC, Roggli VL. Curative resection of a well-differentiated papillary mesothelioma of the pericardium. Arch Pathol Lab Med 1995;119:266–267.PubMedGoogle Scholar
  6. 6.
    Bierhoff E, Pfeifer U. Malignant mesothelioma arising from a benign mediastinal mesothelial cyst. Gen Diagn Pathol 1996;142:59–62.PubMedGoogle Scholar
  7. 7.
    Shimazaki H, Aida S, Iizuka Y, Yoshizu H, Tamai S. Vacuolated cell mesothelioma of the pericardium resembling liposarcoma: a case report. Hum Pathol 2000;31:767–770.PubMedCrossRefGoogle Scholar
  8. 8.
    Antman KH. Current concepts: malignant mesothelioma. N Engl Med 1980;303:200–202.Google Scholar
  9. 9.
    Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP, et al. Localized malignant mesothelioma. Am J Surg Pathol 2005;29:866–873.PubMedCrossRefGoogle Scholar
  10. 10.
    McAllister HA, Hall RJ, Cooley DA. Surgical pathology of tumors and cysts of the heart and pericardium. In: Waller BF, editor. Pathology of the heart and great vessels, New York: Churchill Livingstone; 1988. p. 343–366.Google Scholar
  11. 11.
    Vandercruysse D, Verschakelen JA, Deneffe G. Localized pleural mesothelioma. J Belge Radiol 1993;76:163–166.PubMedGoogle Scholar
  12. 12.
    Ojeda HF, Mech K Jr, Hicken WJ. Localized malignant mesothelioma: a case report. Am Surg 1998;64:881–885.PubMedGoogle Scholar
  13. 13.
    Vogelzang NJ, Rusthoven JJ, Symanowski J, Denham C, Kaukel E, Ruffie P, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21:2636–2644.PubMedCrossRefGoogle Scholar
  14. 14.
    Ordóñez NG. Immunohistochemical diagnosis of epithelioid mesotheliomas: a critical review of old markers, new markers. Hum Pathol 2002;33:953–967.PubMedCrossRefGoogle Scholar
  15. 15.
    Yao DX, Shia J, Erlandson RA, Klimstra DS. Lymphohistiocytoid mesothelioma: a clinical, immunohistochemical and ultrastructural study of four cases and literature review. Ultrastruct Pathol 2004;28:213–228.PubMedCrossRefGoogle Scholar
  16. 16.
    Henderson DW, Attwood HD, Constance TJ, Shilkin KB, Steele RH. Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. Ultrastruct Pathol 1988;12:367–384.PubMedCrossRefGoogle Scholar
  17. 17.
    Khalidi HS, Medeiros LJ, Battifora H. Lymphohistiocytoid mesothelioma. An often misdiagnosed variant of sarcomatoid malignant mesothelioma. Am J Clin Pathol 2000;113:649–654.PubMedCrossRefGoogle Scholar

Copyright information

© Springer 2008

Authors and Affiliations

  • Shintaro Akamoto
    • 1
    • 3
  • Yasuhiko Ono
    • 1
  • Kazumi Ota
    • 1
  • Norikazu Suzaki
    • 1
  • Akinori Sasaki
    • 1
  • Yoshihiro Matsuo
    • 1
  • Kazuhiko Hayashi
    • 2
  1. 1.Department of SurgeryJyuzen General HospitalEhimeJapan
  2. 2.Division of Molecular PathologyTottori University Faculty of MedicineTottoriJapan
  3. 3.Department of Gastroenterological Surgery, Faculty of MedicineKagawa UniversityKagawaJapan

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