Favorable Effects of Preoperative Enteral Immunonutrition on a Surgical Site Infection in Patients with Colorectal Cancer Without Malnutrition
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A prospective study was conducted to ascertain the effects of preoperative enteral immunonutrition on a surgical site infection (SSI) in patients with colorectal cancer without malnutrition.
Patients with colorectal cancer undergoing elective surgery without malnutrition, bowel obstruction, severe cardiopulmonary complications, diabetes, collagen disease, or renal failure were sequentially divided into an immunonutrition group (n = 33) and a control group (n = 34). In the immunonutrition group, an enteral diet supplemented with arginine, dietary nucleotides, and ω-3 fatty acids was administered for 5 days (750 ml/day) prior to surgery.
The mean age was slightly higher in the immunonutrition group (69 ± 9 years) than in the control group (63 ± 11 years; P < 0.05), but no significant differences between the groups were noted for the body mass index, total protein, albumin, hemoglobin, surgical methods, operation time, or volume of intraoperative bleeding. The frequencies of superficial incisional SSI, deep incisional SSI and organ/space SSI in the immunonutrition and control groups were 0% and 11.8% (4/34; P < 0.05), 0% and 0%, and 0% and 2.9% (1/34), respectively.
Preoperative enteral immunonutrition appears to be effective for preventing SSI in patients with colorectal cancer without malnutrition.
- 10.Anaya, DA, Dellinger, EP 2004Surgical infections and choice of antibioticsTownsend, CMBeauchamp, RDEvers, BMMattox, KL eds. Sabiston textbook of surgery: the biological basis of modern surgical practice17th edElsevierPhiladelphia25782Google Scholar
- 11.A report from the NNIS System. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004, Am J Infect Control 2004;32:470–85Google Scholar
- 21.ASPEN committee2001Consensus recommendations from the U.S. summit on immune-enhancing enteral therapyJ Parenteral Enteral Nutr26S613Google Scholar
- 23.Weimann, A, Bastian, L, Bischoff, WE, Grotz, M, Hansel, M, Lotz, J, et al. 1998Influence of arginine, omega-3 fatty acids and nucleotide-supplemented enteral support on systemicinflammatory response syndrome and multiple organ failure in patients after severe traumaNutrition1416572PubMedCrossRefGoogle Scholar