Surgery Today

, Volume 36, Issue 11, pp 1012–1014 | Cite as

Metachronous Mature Cystic Teratomas in the Left Ovary and Bilateral Diaphragm: Report of a Case

  • Hidenobu Okino
  • Yutaka Koga
  • Masazumi Tsuneyoshi
  • Shigeaki Takeda


Mature cystic teratomas are found often in gonadal sites, but rarely in extragonadal sites, such as the retroperitoneum, mediastinum, central nerve system, lung, and liver. To our knowledge, only seven cases of pathologically benign mature cystic teratoma originating in the diaphragm have been reported. We report the case of a 45-year-old woman found to have a mature cystic teratoma below the left side of her diaphragm. She had undergone oophorectomy for a huge mature cystic teratoma in the left ovary 34 years earlier, followed 1 year later by excision of a tumor in the right side of the diaphragm. All sections of the pathological specimen showed evidence of a mature cystic teratoma and pathologically resembled the specimens obtained in the previous two operations. Although this tumor might have been a recurrence of the mature cystic teratoma in the left ovary, it is more likely that multicentric teratomatous foci metachronously developed in the gonadal and extragonadal sites.

Key words

Mature cystic teratoma Ovary Diaphragm 


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  1. 1.
    Kommoss F, Emond J, Hast J. Ruptured mature cystic teratoma of the ovary with recurrence in the liver and colon 17 years later: A case report. J Reprod Med 1990;35:827–31Google Scholar
  2. 2.
    Chen, LM, Nelson, SD, Berek, JS 1999Recurrent mature cystic teratoma presenting as a perihepatic massObstet Gynecol94856PubMedCrossRefGoogle Scholar
  3. 3.
    Brohee, G 1947Tumeurs primitives du diaphragmeActa Chir Belg750735Google Scholar
  4. 4.
    Desjacques, R, Vuillard, P, Douillet, P 1965Kyste sereux peritoneal de la face inferieure du diaphragma (stimulant une tumeur gastrique benigne)Presse Med7312978PubMedGoogle Scholar
  5. 5.
    Dobek, J, Majewski, C, Moll, J 1967A case of teratomatous cyst of the diaphragmPrzegl Lek237979Google Scholar
  6. 6.
    Anan'ev, VM, Gurevich, SS, Rostovtseva, ID 1976Differentiated teratoma of the diaphragmGrudn Khir11178PubMedGoogle Scholar
  7. 7.
    Dubost C, Hugues FC, Gossot D. Cystic teratoma of the diaphragm. A case report and literature review. J Chir 1984;121:273–6Google Scholar
  8. 8.
    Muller, NL 1986CT features of cystic teratoma of the diaphragmJ Comput Assist Tomogr103256PubMedCrossRefGoogle Scholar
  9. 9.
    Rezgui-Marhoul, L, Said, W, Karkni, A 2003A patient with a diaphragmatic massRev Pneumol Clin593813PubMedGoogle Scholar
  10. 10.
    Langley, FA, Fox, H 1995

    Ovarian tumors: classification, histogenesis and aetiology

    Fox, HWells, M eds. Obstetrical and gynaecological pathology4th edChurchill LivingstoneNew York72742
    Google Scholar
  11. 11.
    Steigrad, SJ 1997A case of many ovarian cystectomiesAust NZ J Obstet Gynaecol374802Google Scholar
  12. 12.
    Levavi, H, Kaplan, B, Sabah, G 1996Recurrent bilateral dermoid cysts in accessory ovariesActa Obstet Gynecol Scand757689PubMedGoogle Scholar
  13. 13.
    Müller AM, Söndgen D, Strunz R. Gliomatosis peritonei: a report of two cases and review of the literature. Eur J Obstet Gynecol Reprod Biol 2002;100:213–22Google Scholar
  14. 14.
    Dadmanesh, F, Miller, DM, Swenerton, KD 1997Gliomatosis peritonei with malignant transformationMod Pathol10597601PubMedGoogle Scholar
  15. 15.
    Yadav, A, Lellouch-Tubiana, A, Fournet, JC 1999Glioblastoma multiforme in a mature ovarian teratoma with recurring brain tumoursHistopathology351703PubMedCrossRefGoogle Scholar
  16. 16.
    Lee, YC, Abulafia, O, Montalto, N 1999Malignant transformation of an ovarian mature cystic teratoma presenting as a rectal massGynecol Oncol75499503PubMedCrossRefGoogle Scholar
  17. 17.
    Levanat, S, Kappler, R, Hemmerlein, B 2004Analysis of the PTCH1 signaling pathway in ovarian dermoidsInt J Mol Med147939PubMedGoogle Scholar
  18. 18.
    Lakkis, WG, Martin, MC, Gelfand, MM 1985Benign cystic teratoma of the ovary: a 6-year reviewCan J Surg284446PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Hidenobu Okino
    • 1
  • Yutaka Koga
    • 2
  • Masazumi Tsuneyoshi
    • 2
  • Shigeaki Takeda
    • 1
  1. 1.Departments of Surgery and Clinical ResearchNational Hospital Organization, Kokura HospitalKitakyushuJapan
  2. 2.Department of Anatomic PathologyGraduate School of Medical Sciences, Kyushu UniversityFukuokaJapan

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