Surgery Today

, Volume 36, Issue 6, pp 559–562

Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis Successfully Treated by Immunotherapy with CD3-Activated T Cells and Dendritic Cells After Surgery: Report of a Case

  • Ryota Higuchi
  • Masakazu Yamamoto
  • Takashi Hatori
  • Koichi Shimizu
  • Kenichirou Imai
  • Ken Takasaki
Article

Abstract

Intrahepatic cholangiocarcinoma (ICC) with lymph node (LN) metastasis is generally associated with a poor prognosis. However, we treated ICC with LN metastasis successfully by surgery and postoperative immunotherapy in a 59-year-old woman. The immunotherapy consisted of CD3-activated T cells and tumor lysate- or peptide-pulsed dendritic cells. Pathological examination confirmed a diagnosis of moderately differentiated adenocarcinoma with LN metastasis and portal vein invasion. The patient has been alive without recurrence for 3 years 6 months since her operation.

Key words

Intrahepatic cholangiocarcinoma Lymph node metastasis 

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Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Ryota Higuchi
    • 1
  • Masakazu Yamamoto
    • 1
  • Takashi Hatori
    • 1
  • Koichi Shimizu
    • 1
  • Kenichirou Imai
    • 1
  • Ken Takasaki
    • 1
  1. 1.Department of Surgery, Institute of GastroenterologyTokyo Women's Medical UniversityTokyoJapan

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