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Surgery Today

, Volume 36, Issue 5, pp 436–440 | Cite as

Effect of Peritoneal Lavage with Taurolidine on Primary Colonic Anastomosis in a Rat Model of Secondary Peritonitis

  • Aşkın Akkuş
  • Mustafa Gülmen
  • Ayhan Çevik
  • Nejdet Bildik
  • Orhan Şad
  • Erdem Öztürk
  • Nagihan Özdemir Barışık
Article

Abstract

Purpose

The reported antibacterial, antiendotoxic, and antiadhesive effects of taurolidine prompted us to study the benefits of intraperitoneal lavage with taurolidine on primary colonic anastomosis in a rat model of secondary peritonitis.

Methods

We induced peritonitis in 40 rats by injecting Escherichia coli isolate intraperitoneally. We performed colonic resection and primary anastomosis 5 h later, after lavage with either taurolidine or saline solution. After the rats were killed, on postoperative day (POD) 3 (n = 10) or 7 (n = 10), we measured the bursting pressures and hydroxyproline levels, then examined the resected specimens histologically.

Results

Bursting pressures and tissue hydroxyproline levels were significantly higher in the taurolidine group than in the control group on PODs 3 and 7 (P < 0.05). Histopathological examination revealed significantly higher fibroblastic activity in the taurolidine group.

Conclusions

The higher bursting pressures and tissue hydroxyproline levels in the rats given taurolidine showed the positive effect of taurolidine on anastomotic strength in secondary peritonitis. Taurolidine is a novel antibiotic with both antibacterial and antiendotoxic effects. Intraperitoneal lavage with taurolidine solution may reduce the risks associated with performing primary colonic anastomosis in patients with secondary peritonitis.

Key words

Taurolidine Secondary peritonitis Colonic anastomosis 

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Copyright information

© Springer-Verlag Tokyo 2006

Authors and Affiliations

  • Aşkın Akkuş
    • 1
  • Mustafa Gülmen
    • 1
  • Ayhan Çevik
    • 1
  • Nejdet Bildik
    • 1
  • Orhan Şad
    • 1
  • Erdem Öztürk
    • 1
  • Nagihan Özdemir Barışık
    • 2
  1. 1.Second Surgery ClinicDr. Lütfi Kırdar Education and Research HospitalIstanbulTurkey
  2. 2.Department of PathologyDr. Lütfi Kırdar Education and Research HospitalIstanbulTurkey

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