Advertisement

Surgery Today

, Volume 35, Issue 7, pp 590–593 | Cite as

Granulocyte-Colony Stimulating Factor-Producing Gallbladder Cancer Without Recurrence More than 2 Years After Resection: Report of a Case

  • Tetsuo Ikeda
  • Kippei Ohgaki
  • Masatoku Miura
  • Shinichi Aishima
  • Toshihisa Shimizu
  • Yoshihiko Maehara
Article

Abstract

Patients with gallbladder carcinoma rarely have remarkable granulocytosis. Although surgical resection is the most effective treatment, patients with gallbladder carcinoma generally have a very poor prognosis. We report a case of a rapidly growing gallbladder tumor associated with remarkable granulocytosis in a patient who has survived without recurrence for more than 2 years since undergoing resection. The patient had remarkable leukocytosis of 51 500/mm3 with 89% granulocytes and an elevated granulocyte-colony stimulating factor (G-CSF) level of 800 pg/dl. We performed cholecystectomy with extended right lobectomy of the liver and lymph node dissection. A histological diagnosis of moderately differentiated gallbladder carcinoma with sarcomatous change invading the hepatic parenchyma was confirmed. An immunohistochemical examination using polyclonal antibody against G-CSF was performed to stain the tumor cells, which confirmed the diagnosis of a G-CSF-producing tumor.

Key words

Granulocyte-colony stimulating factor Gallbladder cancer Immunohistochemistry 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Asano, S, Urabe, A, Okabe, T, Sato, N, Kondo, Y 1977Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissueBlood4984552PubMedGoogle Scholar
  2. 2.
    Nishimaki, T, Yoshida, K, Takakuma, K, Hirota, M, Muto, T, Takahashi, M,  et al. 1982A case of carcinoma of the gallbladder producing colony stimulating factor (CSFNippon Shokakibyo Gakkai Zasshi79133640PubMedGoogle Scholar
  3. 3.
    Takahashi, M, Fujiwara, M, Kishi, K, Sakai, C, Sanada, M, Moriyama, Y,  et al. 1985CSF producing gall bladder cancer: case report and characteristics of the CSF produced by tumor cellsInt J Cell Cloning3294303PubMedGoogle Scholar
  4. 4.
    Sakamoto, K, Egami, H, Yoshimura, R, Nakamura, S, Ikei, S, Mori, K,  et al. 1986Colony-stimulating factor producing carcinoma of the gallbladderJpn J Clin Oncol168796PubMedGoogle Scholar
  5. 5.
    Watanabe, Y, Ogino, Y, Ubukata, E, Sakamoto, Y, Matsuzaki, O, Shimizu, N 1989A case of a gallbladder cancer with marked hypercalcemia and leukocytosisJpn J Med287226PubMedGoogle Scholar
  6. 6.
    Takeda, T, Ichiyanagi, A, Sano, A, Yoshida, J, Tsutsumi, Y, Miyaji, T 1990A case of gallbladder cancer producing granulocyte-colony-stimulating factorGastroenterol Jpn257627PubMedGoogle Scholar
  7. 7.
    Omura, N, Abe, S, Hirai, K, Aoki, T 1999A case of granulocyte-colony stimulating factor producing gallbladder cancerAm J Gastroenterol942735CrossRefPubMedGoogle Scholar
  8. 8.
    Kuroki, M, Uto, H, Ido, A, Kuwata, G, Nakama, T, Ochiai, T,  et al. 2000A case of gallbladder cancer producing granulocyte-colony stimulating factor and possible parathyroid hormone related proteinNippon Shokakibyo Gakkai Zasshi9747883PubMedGoogle Scholar
  9. 9.
    Kakinoki, K, Takemori, Y, Noda, Y, Hoso, M 2000An autopsy case of intrahepatic cholangiocarcinoma producing granulocyte-colony stimulating factorNippon Shokakibyo Gakkai Zasshi9711659PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Tetsuo Ikeda
    • 1
  • Kippei Ohgaki
    • 2
  • Masatoku Miura
    • 3
  • Shinichi Aishima
    • 4
  • Toshihisa Shimizu
    • 5
  • Yoshihiko Maehara
    • 6
  1. 1.Department of SurgerySaiseikai Fukuoka General HospitalFukuokaJapan
  2. 2.Departments of SurgerySaiseikai Prefectural HospitalKaratsuJapan
  3. 3.Departments of MedicineSaiseikai Prefectural HospitalKaratsuJapan
  4. 4.Departments of Anatomic Pathology, Granduate School of Medical SciencesKyushu UniversityFukuokaJapan
  5. 5.Departments of RadiologySaiseikai Prefectural HospitalKaratsuJapan
  6. 6.Departments of Surgery and Science, Granduate School of Medical SciencesKyushu UniversityFukuokaJapan

Personalised recommendations