Surgery Today

, Volume 35, Issue 7, pp 590–593 | Cite as

Granulocyte-Colony Stimulating Factor-Producing Gallbladder Cancer Without Recurrence More than 2 Years After Resection: Report of a Case

  • Tetsuo Ikeda
  • Kippei Ohgaki
  • Masatoku Miura
  • Shinichi Aishima
  • Toshihisa Shimizu
  • Yoshihiko Maehara


Patients with gallbladder carcinoma rarely have remarkable granulocytosis. Although surgical resection is the most effective treatment, patients with gallbladder carcinoma generally have a very poor prognosis. We report a case of a rapidly growing gallbladder tumor associated with remarkable granulocytosis in a patient who has survived without recurrence for more than 2 years since undergoing resection. The patient had remarkable leukocytosis of 51 500/mm3 with 89% granulocytes and an elevated granulocyte-colony stimulating factor (G-CSF) level of 800 pg/dl. We performed cholecystectomy with extended right lobectomy of the liver and lymph node dissection. A histological diagnosis of moderately differentiated gallbladder carcinoma with sarcomatous change invading the hepatic parenchyma was confirmed. An immunohistochemical examination using polyclonal antibody against G-CSF was performed to stain the tumor cells, which confirmed the diagnosis of a G-CSF-producing tumor.

Key words

Granulocyte-colony stimulating factor Gallbladder cancer Immunohistochemistry 


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Copyright information

© Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Tetsuo Ikeda
    • 1
  • Kippei Ohgaki
    • 2
  • Masatoku Miura
    • 3
  • Shinichi Aishima
    • 4
  • Toshihisa Shimizu
    • 5
  • Yoshihiko Maehara
    • 6
  1. 1.Department of SurgerySaiseikai Fukuoka General HospitalFukuokaJapan
  2. 2.Departments of SurgerySaiseikai Prefectural HospitalKaratsuJapan
  3. 3.Departments of MedicineSaiseikai Prefectural HospitalKaratsuJapan
  4. 4.Departments of Anatomic Pathology, Granduate School of Medical SciencesKyushu UniversityFukuokaJapan
  5. 5.Departments of RadiologySaiseikai Prefectural HospitalKaratsuJapan
  6. 6.Departments of Surgery and Science, Granduate School of Medical SciencesKyushu UniversityFukuokaJapan

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