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Surgery Today

, Volume 33, Issue 12, pp 896–901 | Cite as

The Effects of Melatonin on Angiogenesis and Wound Healing

  • GÜrsel Soybİr
  • Cemalettin Topuzlu
  • ÖzgÜr OdabaŞ
  • Kemal Dolay
  • Ayhan Bİlİr
  • Ferda KÖksoy
Article

Purpose

The pineal gland hormone melatonin is a well-known neoroendocrine hormone. In addition to its immunomodulator effect, it also has a positive effect on monocyte, cytokine, and fibroblast proliferations, which also influence angiogenesis. This study investigated the effects of melatonin hormone on angiogenesis in wound healing on 100 Wistar-Albino rats.

Methods

The rats were divided into two groups. Melatonin dissolved in 0.9% NaCl was administered to the study group in a dose of 0.4 mg/kg/rat per day (0.25 cc/rat per day), and 0.9% NaCl to the control group in a dose of 0.25 cc/rat per day. Incisions 5 cm in length were made on the back skin of the rats and the wounds were closed with a skin stapler. Excisional biopsies from healing tissues were taken on the 3rd, 7th, 10th, 14th, and 21st postoperative days. Angiogenesis was evaluated in healing tissues by light and electron microscopy and by hydroxyproline level measurements.

Results

The commencement of neovascularization and a significant increase (P ≪ 0.05) in the number of vessels were observed at all stages of the study group but not in the control group. The tissue hydroxyproline levels were also higher in the study group than in the control group.

Conclusions

Melatonin may have a positive effect on both angiogenesis and wound healing.

Key words

Wound healing Angiogenesis Melatonin 

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Copyright information

© Springer-Verlag Tokyo 2003

Authors and Affiliations

  • GÜrsel Soybİr
    • 1
  • Cemalettin Topuzlu
    • 2
  • ÖzgÜr OdabaŞ
    • 1
  • Kemal Dolay
    • 1
  • Ayhan Bİlİr
    • 3
  • Ferda KÖksoy
    • 4
  1. 1.Department of SurgeryHaseki Educational and Research State HospitalIstanbulTurkey
  2. 2.Department of SurgeryIstanbul University Institute of OncologyIstanbulTurkey
  3. 3.Department of HistologyIstanbul University, Istanbul Medical SchoolIstanbulTurkey
  4. 4.Department of SurgeryTaksim Educational and Research State HospitalIstanbulTurkey

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