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Acta Diabetologica

, Volume 35, Issue 3, pp 150–153 | Cite as

Hepatocyte nuclear factor-1a gene and non-insulin-dependent diabetes mellitus in the Japanese population

  • N. Babaya
  • H. Ikegami
  • Y. Kawaguchi
  • T. Fujisawa
  • Y. Nakagawa
  • Y. Hamada
  • M. Hotta
  • H. Ueda
  • M. Shintani
  • K. Nojima
  • Y. Kawabata
  • M. Ono
  • K. Yamada
  • G.-Q. Shen
  • M. Fukuda
  • T. Ogihara
ORIGINAL

Abstract

Recently, hepatocyte nuclear factor-1α (HNF-1α, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non-insulin-dependent diabetes mellitus (type 2) in Japanese subjects by investigating allelic association with type 2 diabetes use of three markers. We also studied the frequency of the G191D mutation, the only mutation of TCF1 reported so far in late-onset type 2 diabetes. A total of 356 subjects were studied. There were no significant differences in allele frequency of the three markers between patients with type 2 diabetes and control subjects. A G191D mutation was not found in the subjects studied, giving a frequency of less than 0.4% in common type 2 diabetes. The lack of association of type 2 diabetes with three markers in and near TCF1 suggests that mutations in TCF1 derived from a limited number of founders are not a major cause of common type 2 diabetes even in the genetically homogeneous Japanese population. The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese.

Key words Non-insulin-dependent diabetes mellitus MODY Hepatocyte nuclear factor-1α Genetics Microsatellite polymorphism 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • N. Babaya
    • 1
  • H. Ikegami
    • 1
  • Y. Kawaguchi
    • 1
  • T. Fujisawa
    • 1
  • Y. Nakagawa
    • 1
  • Y. Hamada
    • 1
  • M. Hotta
    • 1
  • H. Ueda
    • 1
  • M. Shintani
    • 1
  • K. Nojima
    • 1
  • Y. Kawabata
    • 1
  • M. Ono
    • 1
  • K. Yamada
    • 1
  • G.-Q. Shen
    • 1
  • M. Fukuda
    • 2
  • T. Ogihara
    • 1
  1. 1.Department of Geriatric Medicine, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565, JapanJP
  2. 2.Osaka Teishin Hospital, Osaka, JapanJP

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