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Acta Diabetologica

, Volume 35, Issue 2, pp 77–80 | Cite as

Elevated hepatocyte growth factor in sera from patients with insulin-dependent diabetes mellitus

  • B. Kulseng
  • M. Børset
  • T. Espevik
  • A. Sundan
ORIGINAL

Abstract

Hepatocyte growth factor (HGF) is a pleiotropic cytokine known to be involved in tissue regeneration and repair. We measured serum levels of HGF in patients with insulin-dependent diabetes mellitus (type 1). The patients were divided into four groups: (1) 10 patients at clinical presentation before insulin treatment; (2) 19 patients with newly diagnosed type 1 diabetes (diabetes duration 1/2–3 years); (3) 14 patients with long-standing type 1 diabetes without renal involvement (diabetes duration >10 years, and urinary albumin excretion (UAER) <20 μg/ min); and (4) 20 patients with long-standing type 1 diabetes with renal involvement (diabetes duration >10 years and UAER 20–500 μg/min). Sera from 24 age- and sex-matched healthy blood donors constituted a control group. The HGF levels of the four groups were (mean±SD); group 1, 0.74±0.14; group 2, 0.78±0.40; group 3, 0.86±0.42; group 4, 0.79±0.27 ng/ml, compared to 0.43±0.24 ng/ml in the control group (P<0.0008). HGF levels were not significantly different between the four patient groups. The elevated serum HGF levels did not correlate with complications related to type 1 diabetes, such as UAER, retinopathy and macrovascular complications, suggesting that HGF levels were not associated with the type 1 diabetes complications. In conclusion, our results show that type 1 diabetic patients have increased serum HGF levels compared with controls and that HGF is elevated to the same extent in newly diagnosed as well as in long-standing type 1 diabetes.

Key words Hepatocyte growth factor HGF Insulin-dependent diabetes mellitus Microalbuminuria Diabetic complications 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • B. Kulseng
    • 1
  • M. Børset
    • 1
  • T. Espevik
    • 1
  • A. Sundan
    • 1
  1. 1.Institute of Cancer Research and Molecular Biology, Medisinsk Teknisk Senter, N-7006 Trondheim, NorwayNO

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