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A common polymorphism in MIR155 gene promoter region is associated with a lower risk to develop type 2 diabetes

  • Andrea Latini
  • Vincenza Spallone
  • Cinzia D’Amato
  • Giuseppe Novelli
  • Paola Borgiani
  • Cinzia CiccacciEmail author
Letter to the Editor
  • 52 Downloads

Dear Editor,

We read with great interest the paper “Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus” by Assmann et al. [1]. The authors described the association between two polymorphisms in MIR155 and MIR146A genes and susceptibility to type 1 diabetes. It is known that these miRNAs are involved in immunity and inflammation pathways; therefore, it is conceivable that they could also play a role in type 2 diabetes mellitus (T2DM) susceptibility. In a previous publication, we had investigated MIR146a rs2910164 polymorphism in relation to T2DM susceptibility but we did not observe significant differences of frequencies between T2DM patients and healthy controls [2].

Since, at present time, there are no data in literature related to the effect of MIR155 polymorphisms in the susceptibility to T2DM, we examined the MIR155rs767649 (A/T) in 233 patients with T2DM recruited from outpatients attending the Diabetic Clinic of the...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

All procedures were performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    Assmann TS, Duarte GC, Brondani LA et al (2017) Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus. Acta Diabetol 54:433–441CrossRefGoogle Scholar
  2. 2.
    Ciccacci C, Di Fusco D, Cacciotti L et al (2013) MicroRNA genetic variations: association with type 2 diabetes. Acta Diabetol 50:867–872CrossRefGoogle Scholar
  3. 3.
    Xie K, Ma H, Liang C et al (2015) A functional variant in miR-155 regulation region contributes to lung cancer risk and survival. Oncotarget 6:42781–42792PubMedPubMedCentralGoogle Scholar
  4. 4.
    Mahdavi R, Ghorbani S, Alipoor B et al (2018) Decreased serum level of miR-155 is associated with obesity and its related metabolic traits. Clin Lab 64:77–84CrossRefGoogle Scholar
  5. 5.
    Qiu XK, Ma J (2018) Alteration in microRNA-155 level correspond to severity of coronary heart disease. Scand J Clin Lab Invest 78:219–223CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2019

Authors and Affiliations

  • Andrea Latini
    • 1
  • Vincenza Spallone
    • 2
  • Cinzia D’Amato
    • 2
  • Giuseppe Novelli
    • 1
  • Paola Borgiani
    • 1
  • Cinzia Ciccacci
    • 1
    Email author
  1. 1.Department of Biomedicine and Prevention, Genetics SectionUniversity of Rome “Tor Vergata”RomeItaly
  2. 2.Department of Systems Medicine, EndocrinologyUniversity of Rome “Tor Vergata”RomeItaly

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