A common polymorphism in MIR155 gene promoter region is associated with a lower risk to develop type 2 diabetes
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We read with great interest the paper “Polymorphisms in genes encoding miR-155 and miR-146a are associated with protection to type 1 diabetes mellitus” by Assmann et al. . The authors described the association between two polymorphisms in MIR155 and MIR146A genes and susceptibility to type 1 diabetes. It is known that these miRNAs are involved in immunity and inflammation pathways; therefore, it is conceivable that they could also play a role in type 2 diabetes mellitus (T2DM) susceptibility. In a previous publication, we had investigated MIR146a rs2910164 polymorphism in relation to T2DM susceptibility but we did not observe significant differences of frequencies between T2DM patients and healthy controls .
Since, at present time, there are no data in literature related to the effect of MIR155 polymorphisms in the susceptibility to T2DM, we examined the MIR155rs767649 (A/T) in 233 patients with T2DM recruited from outpatients attending the Diabetic Clinic of the...
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Conflict of interest
The authors declare that they have no conflict of interest.
All procedures were performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments
Informed consent was obtained from all individual participants included in the study.