Acta Diabetologica

, Volume 55, Issue 9, pp 943–953 | Cite as

Prevalence and predictors of depression and anxiety in adult patients with type 1 diabetes in tertiary care setting

  • A. M. Castellano-Guerrero
  • R. Guerrero
  • F. Relimpio
  • F. Losada
  • M. A. Mangas
  • A. Pumar
  • M A. Martínez-BroccaEmail author
Original Article



To determine gender and age differences in the prevalence of depression and anxiety and their predictive factors in adult patients with type 1 diabetes (DM1).


Random sample of DM1 adult patients from a tertiary care hospital cohort. To evaluate the presence of depression and anxiety, psychological evaluation was performed using structured clinical interview (MINI). For the specific evaluation of fear of hypoglycemia (FH), FH-15 questionnaire was used.


339 patients [51.6% male; 38.5 ± 12.9 years; HbA1c 7.5 ± 1.1% (58.5 ± 14.2 mmol/mol); 20.1 ± 12.0 years of DM1] met the inclusion criteria. Prevalence of depression, anxiety, and FH in men vs. women was as follows (%): depression: 15.4 vs. 33.5 (p < 0.05); anxiety: 13.7 vs. 26.2 (p < 0.05); and FH: 42.8 vs. 46.0 (p = NS). Among midlife female patients, prevalence of depression and anxiety was higher compared to male. Moreover, comorbid depressive and anxious symptoms were also higher in midlife female patients compared to age-matched male patients (3.5 vs. 14%, p < 0.05). Apart from age-related vulnerability, female gender, poor glycemic control, and microvascular and macrovascular complications were predictive factors for depressive and anxious symptomatology. Unawareness hypoglycemia and anxiety-prone personality were predictor factors for FH.


In adults with DM1, prevalence of depression and anxiety is higher in women. Midlife patients, in particular women, show a significantly higher prevalence of anxiety symptoms and comorbid depression and anxiety. The presence of secondary complications and sustained poor glycemic control should alert to the possibility of these mental disorders, especially in the most vulnerable age population; clinical, gender and age-related patterns could help to design more effective psychological assessment and support in adult patients with DM1.


Type 1 diabetes mellitus Depression Anxiety Gender differences Age difference Fear of hypoglycemia 



The authors thank Sofía Perea, Pharm D, PhD, for her support in writing the manuscript.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Compliance with ethical standards

Conflict of interest

The authors have declared no conflict of interest.

Ethical Standard

The study was reviewed by the local Ethics Committee and has been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki.

Informed consent

All persons gave their informed consent prior to their inclusion in the study.


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Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  • A. M. Castellano-Guerrero
    • 1
  • R. Guerrero
    • 1
    • 3
  • F. Relimpio
    • 1
    • 3
  • F. Losada
    • 1
    • 3
  • M. A. Mangas
    • 1
    • 3
  • A. Pumar
    • 1
    • 3
  • M A. Martínez-Brocca
    • 2
    • 3
    Email author
  1. 1.Unidad de Gestión Clínica de Endocrinología y NutriciónHospital Universitario Virgen del RocíoSevilleSpain
  2. 2.Unidad de Gestión Clínica de Endocrinología y NutriciónHospital Universitario Virgen MacarenaSevilleSpain
  3. 3.Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Consejo Superior de Investigaciones Científicas/Universidad de SevillaSevilleSpain

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