Advertisement

Acta Diabetologica

, Volume 55, Issue 7, pp 751–754 | Cite as

Postpartum resolution of obstructive sleep apnea in women with gestational diabetes and the relationship with glucose metabolism

  • Somvang Amnakkittikul
  • Naricha Chirakalwasan
  • Ekasitt Wanitcharoenkul
  • Suranut Charoensri
  • Sunee Saetung
  • Suwannee Chanprasertyothin
  • La-or Chailurkit
  • Panyu Panburana
  • Sommart Bumrungphuet
  • Sirimon Reutrakul
Short Communication

Introduction

Gestational diabetes (GDM) affects 4 to 9% of pregnancy. Obstructive sleep apnea (OSA) is increasingly recognized as a risk factor for GDM [1]. OSA is a common sleep disorder characterized by complete or partial obstruction of the upper airway causing intermittent hypoxia and sleep fragmentation. During pregnancy, changes in hormonal status, mucosal edema, and body habitus may predispose women to OSA, especially in obese women. In a non-pregnant population, OSA is a risk factor for diabetes [1]. No studies have explored whether OSA improves after delivery in women with GDM and OSA diagnosed during pregnancy, and how this relates to glucose metabolism. In addition, how other sleep disturbances (i.e., poor sleep quality and inadequate sleep duration), shown to be diabetes risk factors in non-pregnant population, affect glucose metabolism during postpartum period has not been extensively explored.

Materials and methods

Obese postpartum participants (pre-pregnancy body mass...

Keywords

Gestational diabetes Obstructive sleep apnea Sleep duration Sleep quality Postpartum Prediabetes 

Notes

Acknowledgements

We would like to thank Dr. Eve Van Cauter, Ph.D., The Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, and Sleep, Metabolism and Health Center, Department of Medicine, The University of Chicago, Chicago, Illinois, USA, for her critical suggestions for the study. We would like to thank all the participants.

Funding source

This study was funded by The Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. The funder had no role in study design or interpretations.

Compliance with ethical standards

Conflict of interest

Dr. Reutrakul reports grants from Merck Sharp and Dohme, non-financial support from ResMed, personal fees from Novo Nordisk, personal fees from Sanofi Aventis, and personal fees from Medtronic, outside the submitted work. All other authors have nothing to disclose.

Human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients for being included in the study.

References

  1. 1.
    Reutrakul S, Mokhlesi B (2017) Obstructive sleep apnea and diabetes: a state of the art review. Chest 152(5):1070–1086CrossRefPubMedGoogle Scholar
  2. 2.
    Reid J, Glew RA, Skomro R, Fenton M, Cotton D, Olatunbosun F et al (2013) Sleep disordered breathing and gestational hypertension: postpartum follow-up study. Sleep 36(5):717–721CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Ferrari U, Kunzel H, Trondle K, Rottenkolber M, Kohn D, Fugmann M et al (2015) Poor sleep quality is associated with impaired glucose tolerance in women after gestational diabetes. J Psychiatr Res 65:166–171CrossRefPubMedGoogle Scholar
  4. 4.
    Tan X, van Egmond L, Chapman CD, Cedernaes J, Benedict C (2018) Aiding sleep in type 2 diabetes: therapeutic considerations. Lancet Diabetes Endocrinol 6(1):60–68CrossRefPubMedGoogle Scholar
  5. 5.
    Leproult R, Deliens G, Gilson M, Peigneux P (2015) Beneficial impact of sleep extension on fasting insulin sensitivity in adults with habitual sleep restriction. Sleep 35(5):707–715CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l., part of Springer Nature 2018

Authors and Affiliations

  • Somvang Amnakkittikul
    • 1
  • Naricha Chirakalwasan
    • 2
    • 3
  • Ekasitt Wanitcharoenkul
    • 1
  • Suranut Charoensri
    • 1
  • Sunee Saetung
    • 1
  • Suwannee Chanprasertyothin
    • 4
  • La-or Chailurkit
    • 1
  • Panyu Panburana
    • 5
  • Sommart Bumrungphuet
    • 5
  • Sirimon Reutrakul
    • 1
    • 6
  1. 1.Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand
  2. 2.Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of MedicineChulalongkorn UniversityBangkokThailand
  3. 3.Excellence Center for Sleep Disorders, King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkokThailand
  4. 4.Research Center, Department of Medicine, Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand
  5. 5.Division of Maternal and Fetal Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand
  6. 6.Division of Endocrinology, Diabetes and Metabolism, Department of MedicineUniversity of Illinois College of Medicine at ChicagoChicagoUSA

Personalised recommendations