Postpartum resolution of obstructive sleep apnea in women with gestational diabetes and the relationship with glucose metabolism
Gestational diabetes (GDM) affects 4 to 9% of pregnancy. Obstructive sleep apnea (OSA) is increasingly recognized as a risk factor for GDM . OSA is a common sleep disorder characterized by complete or partial obstruction of the upper airway causing intermittent hypoxia and sleep fragmentation. During pregnancy, changes in hormonal status, mucosal edema, and body habitus may predispose women to OSA, especially in obese women. In a non-pregnant population, OSA is a risk factor for diabetes . No studies have explored whether OSA improves after delivery in women with GDM and OSA diagnosed during pregnancy, and how this relates to glucose metabolism. In addition, how other sleep disturbances (i.e., poor sleep quality and inadequate sleep duration), shown to be diabetes risk factors in non-pregnant population, affect glucose metabolism during postpartum period has not been extensively explored.
Materials and methods
Obese postpartum participants (pre-pregnancy body mass...
KeywordsGestational diabetes Obstructive sleep apnea Sleep duration Sleep quality Postpartum Prediabetes
We would like to thank Dr. Eve Van Cauter, Ph.D., The Section of Adult and Pediatric Endocrinology, Diabetes, and Metabolism, and Sleep, Metabolism and Health Center, Department of Medicine, The University of Chicago, Chicago, Illinois, USA, for her critical suggestions for the study. We would like to thank all the participants.
This study was funded by The Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. The funder had no role in study design or interpretations.
Compliance with ethical standards
Conflict of interest
Dr. Reutrakul reports grants from Merck Sharp and Dohme, non-financial support from ResMed, personal fees from Novo Nordisk, personal fees from Sanofi Aventis, and personal fees from Medtronic, outside the submitted work. All other authors have nothing to disclose.
Human and animal rights
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008.
Informed consent was obtained from all patients for being included in the study.