Acta Diabetologica

, Volume 54, Issue 12, pp 1147–1149 | Cite as

Gut microbiota aberrations precede diagnosis of gestational diabetes mellitus

  • Kati Mokkala
  • Noora Houttu
  • Tero Vahlberg
  • Eveliina Munukka
  • Tapani Rönnemaa
  • Kirsi Laitinen
Short Communication

Abbreviations

AUC

The area under curve

GDM

Gestational diabetes

hs-CRP

High sensitive CRP

OR

Odds ratio

OTUs

Operational taxonomic units

Notes

Acknowledgements

The study was funded by the Academy of Finland (#258606), State research funding for university-level health research of the Turku University Hospital Expert Responsibility Area, the Päivikki and Sakari Sohlberg Foundation (personal funding for KM) and the Finnish Cultural Foundation (Varsinais-Suomi Regional Fund) (personal funding for KM).

Author’s contribution

KM and KL designed the study, TV performed the statistical analyses, KM and KL wrote the first draft of the article and finalized the article. All authors contributed to the interpretation of the results and the writing of the manuscript.

Compliance with ethical standards

Conflict of interests

The authors declare that they have no conflict of interests.

Human and animal rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. All procedures performed involving human subjects were approved by the Ethics Committee of the Hospital District of Southwest Finland (Permission No. 115/180/2012).

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

592_2017_1056_MOESM1_ESM.pdf (276 kb)
Supplementary material 1 (PDF 275 kb)
592_2017_1056_MOESM2_ESM.pdf (88 kb)
Supplementary material 2 (PDF 88 kb)

References

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    Le Chatelier E, Nielsen T, Qin J et al (2013) Richness of human gut microbiome correlates with metabolic markers. Nature 500(7464):541–546CrossRefPubMedGoogle Scholar
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    Gomez-Arango LF, Barrett HL, McIntyre HD et al (2016) Connections between the gut microbiome and metabolic hormones in early pregnancy in overweight and obese women. Diabetes 65(8):2214–2223CrossRefPubMedGoogle Scholar
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    Fugmann M, Breier M, Rottenkolber M et al (2015) The stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes. Sci Rep 5:13212. doi: 10.1038/srep13212 CrossRefPubMedPubMedCentralGoogle Scholar
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    Schwiertz A, Taras D, Schäfer K et al (2010) Microbiota and SCFA in lean and overweight healthy subjects. Obesity 18(1):190–195CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia S.r.l. 2017

Authors and Affiliations

  • Kati Mokkala
    • 1
  • Noora Houttu
    • 1
  • Tero Vahlberg
    • 2
  • Eveliina Munukka
    • 1
    • 3
  • Tapani Rönnemaa
    • 4
  • Kirsi Laitinen
    • 1
  1. 1.Institute of BiomedicineUniversity of TurkuTurkuFinland
  2. 2.Department of Clinical Medicine, Biostatistics, Turku University HospitalUniversity of TurkuTurkuFinland
  3. 3.TUCS Microbiology and Genetics, Turku University HospitalUniversity of TurkuTurkuFinland
  4. 4.Department of Medicine, Turku University HospitalUniversity of TurkuTurkuFinland

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