Acta Diabetologica

, Volume 54, Issue 8, pp 769–773 | Cite as

Ischemic index changes in diabetic retinopathy after intravitreal dexamethasone implant using ultra-widefield fluorescein angiography: a pilot study

  • Lea Querques
  • Mariacristina Parravano
  • Riccardo Sacconi
  • Alessandro Rabiolo
  • Francesco Bandello
  • Giuseppe Querques
Original Article



To investigate the effect of dexamethasone intravitreal implant on peripheral ischemia in patients affected by diabetic macular edema (DME).


Patients with treatment-naïve diabetic retinopathy (DR) undergoing intravitreal dexamethasone implant for DME between October 2015 and March 2017 were enrolled. Patients underwent a comprehensive ocular examination at baseline (<2 weeks before treatment) and 10 ± 2 weeks after dexamethasone implant including best-corrected visual acuity (BCVA), intraocular pressure, optical coherence tomography, ultra-widefield (UWF) retinography and UWF fluorescein angiography (UWFA).


Nine eyes of seven consecutive patients (five males; mean age 66.4 ± 6.7 years) were enrolled. Mean duration of DR was 12.3 ± 8.4 years. Mean interval between UWFA acquisitions was 12.1 ± 2.1 weeks, and the mean interval between intravitreal injection and UWFA acquisition was 11.0 ± 1.6 weeks. Mean pre- and post-injection BCVA was 0.30 ± 0.20 and 0.21 ± 0.14 logMAR (p = 0.06), respectively. Mean pre- and post-injection central macular thickness was 449.8 ± 92.5 and 356.3 ± 52.4 μm (p = 0.03), respectively. Mean pre- and post-injection ischemic index was 24.0 ± 25.0 and 9.8 ± 12.1% (p = 0.0427), respectively.


Intravitreal dexamethasone implant reduces peripheral retina ischemia in patients with DR.


Diabetic retinopathy Diabetic macular edema Ultra-widefield fluorescein angiography Ischemic index After intravitreal dexamethasone implant 


Compliance with ethical standards

Conflict of interest

Lea Querques, Alessandro Rabiolo, Maria Cristina Parravano, Riccardo Sacconi declare that they have no conflict of interest. Francesco Bandello consultant for: Alcon (Fort Worth, Texas, USA), Alimera Sciences (Alpharetta, Georgia, USA), Allergan Inc (Irvine, California, USA), Farmila-Thea (Clermont-Ferrand, France), Bayer Shering-Pharma (Berlin, Germany), Bausch And Lomb (Rochester, New York, USA), Genentech (San Francisco, California, USA), Hoffmann-La-Roche (Basel, Switzerland), NovagaliPharma (Évry, France), Novartis (Basel, Switzerland), Sanofi-Aventis (Paris, France), Thrombogenics (Heverlee, Belgium), Zeiss (Dublin, USA). Giuseppe Querques consultant for: Alimera Sciences (Alpharetta, Georgia, USA), Allergan Inc (Irvine, California, USA), Heidelberg (Germany), Novartis (Basel, Switzerland), Bayer Shering-Pharma (Berlin, Germany), Zeiss (Dublin, USA).

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Human and animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Declaration of Helsinki 1975, as revised in 2008.

Informed consent

Informed consent was obtained from all patients for being included in the study.


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Copyright information

© Springer-Verlag Italia 2017

Authors and Affiliations

  • Lea Querques
    • 1
    • 2
  • Mariacristina Parravano
    • 2
  • Riccardo Sacconi
    • 1
    • 3
  • Alessandro Rabiolo
    • 1
  • Francesco Bandello
    • 1
  • Giuseppe Querques
    • 1
  1. 1.Department of OphthalmologyUniversity Vita-Salute, IRCCS Ospedale San RaffaeleMilanItaly
  2. 2.G. B. Bietti Foundation-IRCCSRomeItaly
  3. 3.Eye Clinic, Department of Neurological and Movement SciencesUniversity of VeronaVeronaItaly

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