Maternal hair metabolome analysis identifies a potential marker of lipid peroxidation in gestational diabetes mellitus
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Gestational diabetes mellitus (GDM) is defined as an abnormal glucose tolerance that develops, or is first recognized during pregnancy; the development of GDM markedly increases risks of adverse obstetric and perinatal outcome. The immediate consequences include an increased likelihood of a Caesarean section, hypoglycaemia of the newborn, respiratory distress syndrome, and macrosomia. Longer-term implications of a pregnancy affected by GDM include a substantially increased risk of the mother developing type 2 diabetes postnatally, as well as the offspring having an increased susceptibility to obesity and related metabolic complications in adulthood. Within the Asia–Pacific region there are an estimated 76 million women at risk of having a pregnancy complicated by diabetes, with recent estimates suggesting up to 18 % of pregnancies in China may be complicated by GDM .
Metabolomic profiling is a strategy for investigating the low weight molecules that represent the...
KeywordsGestational Diabetes Mellitus Hair Sample Adipic Acid Fetal Growth Restriction Octanoic Acid
The authors wish to thank Gravida: National Centre for Growth and Development for funding the project. All metabolome analyses were carried out at the Centre for Genomics, Proteomics and Metabolomics of the University of Auckland. K.S. and P.N.B. are supported by Gravida: National Centre for Growth and Development (New Zealand); J.V.D.S. by the Agnes Paykel Trust (New Zealand).
Conflict of interest
Human and animal rights
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 .
Informed consent was obtained from all patients included in the study.