The product of triglycerides and glucose in comparison with fasting plasma glucose did not improve diabetes prediction
Previous study has reported that triglycerides-glucose (TyG) index, a product of triglycerides and fasting plasma glucose (FPG), might be useful in the prediction of incident type 2 diabetes (T2D). We evaluated the ability of the TyG index compared to FPG and OGTT as possible diabetes predictor in nondiabetic first-degree relatives (FDRs) of patients with T2D.
A total of 1,488 FDRs without diabetes of consecutive patients with T2D 30–70 years old (361 men and 1,127 women) were examined and followed for a mean (SD) of 6.9 (1.7) years for diabetes incidence. We examined the incidence of diabetes across quartiles of the TyG index and plotted a receiver operating characteristic (ROC) curve to assess discrimination. At baseline and through follow-up, participants underwent a standard 75-g two-hour oral glucose tolerance test.
During 10,124 person-years of follow-up, 41 men and 154 women developed T2D. Those in the top quartile of TyG index were 3.4 times more likely to develop T2D than those in the bottom quartile (odds ratio 3.36; 95 % CI 1.83, 6.19). On ROC curve analysis, a higher area under the ROC was found for FPG (76.2; 95 % CI 71.9, 80.6), 1-hPG (81.0, 95 % CI 77.2, 84.9) and 2-hPG (76.5; 95 % CI 72.3, 80.8) than for TyG index (65.1; 95 % CI 60.5, 69.7).
TyG index is predicted T2D in high-risk individuals in Iran but FPG, 1-hPG and 2-hPG appeared to be more robust predictor of T2D in our study population.
KeywordsDiabetes mellitus First-degree relatives Glucose tolerance Incidence Risk score Triglycerides and glucose index Product of fasting triglycerides and glucose
The authors are grateful to Mr. Majid Abyar for computer technical assistance. This study was supported partially by a grant from the Isfahan University of Medical Sciences, Iran. This research was performed as a part of the academic activity of the university.
Conflict of interest
Janghorbani M, Almasi SZ and Amini M declare that they have no conflict of interest.
This study was approved by the Institutional Ethics Committee of the Isfahan University of Medical Sciences, Iran.
Human and Animal Rights disclosure
All procedures followed were in accordance with the ethical standards of the Institutional Review Board of Isfahan University of Medical Sciences, Iran and with the Helsinki Declaration of 1975, as revised in 2009 .
Informed consent disclosure
Informed consent was obtained from all patients for being included in the study.
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