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Acta Diabetologica

, Volume 52, Issue 3, pp 483–488 | Cite as

Incidence of type 1 diabetes among Polish children ages 0–14 years from 1989–2012

  • Agata ChobotEmail author
  • Joanna Polanska
  • Grazyna Deja
  • Przemyslawa Jarosz-Chobot
Original Article

Abstract

Aims

The incidence of pediatric type 1 diabetes mellitus (T1DM) in Poland is intermediate relative to the rest of the world. T1DM prevalence in the region of Silesia approximates national estimates for all of Poland. This epidemiologic study aimed to analyze the changes in incidence rates of T1DM among children ages 0–14 years from 1989 to 2012 in this region.

Methods

Data collection methods for the registry followed EURODIAB criteria. To estimate overall population size, data from the Central and regional Statistical Office in Katowice were used. T1DM incidence rates/100,000 children ages 0–14 years/annum and their 95 % CI were calculated for all children and in age subgroups (0–4, 5–9, 10–14 years). For comparative analysis incidence rates were age and sex standardized to the population of Poland in 2005. For statistical analyses open source R Bioconductor software was used.

Results

During this 24-year period, 2,215 new cases (1,146 boys) were diagnosed. The standardized incidence rate rose about 7 % annually. The mean standardized incidence rates estimated in four 6-year time periods (1989–1994, 1995–2000, 2001–2006, 2007–2012) separately showed significant increases from 5.80/100,000/year (1989–1994) through 10.44/100,000/year (1995–2000) and 15.05/100,000/year (2001–2006) to 18.94/100,000/year (2007–2012). From 1989 to 2012, the greatest relative rise in annual incidence (/100,000/year) was among the very young: 2.58–14.00 (0–4 years); 4.96–19.43 (5–9 years); 8.84–22.15 (10–14 years). The highest average annual increment of the incidence rate was in the middle age subgroup (5–9 years). No significant sex difference was observed.

Conclusions

The overall incidence rate increased 3.8 times, suggesting an epidemic of pediatric T1DM in Silesia, Poland. These temporal changes confirm that Poland currently has one of the highest incidence rates of pediatric T1DM in Europe.

Keywords

Type 1 diabetes Epidemiology Incidence rate Children 

Notes

Acknowledgments

We would like to thank the team, especially Dr Eva Gyurus (University of Pecs, Hungary) who continues the EURODIAB program for the conscientiousness in collecting results gathered at the Pecs University, Hungary. We are very grateful to Dr Sanjeev Mehta (Joslin Diabetes Center, Boston, USA) for his essential comments and language corrections. This study was financed by SUT BK/265/RAU1/2014/10 and MNiSW grant IP2012 007672. The analyses were done with the use of IT infrastructure of GeCONiI, POIG 02.03.01-24-099/13.

Conflict of interest

The authors declare no conflict of interest.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Human and animal rights

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.

References

  1. 1.
    International Diabetes Federation (2013) IDF Diabetes Atlas, 6th edn. International Diabetes Federation, BrusselsGoogle Scholar
  2. 2.
    Zhao Z, Sun C, Wang C, Li P, Wang W, Ye J, Gu X, Wang X, Shen S, Zhi D, Lu Z, Ye R, Cheng R, Xi L, Li X, Zheng Z, Zhang M, Luo F (2014) Rapidly rising incidence of childhood type 1 diabetes in Chinese population: epidemiology in Shanghai during 1997–2011. Acta Diabetol. doi: 10.1007/s00592-014-0590-2 Google Scholar
  3. 3.
    Harjutsalo V, Sund R, Knip M, Groop PH (2013) Incidence of type 1 diabetes in Finland. JAMA 310:427–428CrossRefPubMedGoogle Scholar
  4. 4.
    Harjutsalo V, Sjöberg L, Tuomilehto J (2008) Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 371:1777–1782CrossRefPubMedGoogle Scholar
  5. 5.
    Jarosz-Chobot P, Deja G, Polanska J (2010) Epidemiology of type 1 diabetes among Silesian children aged 0–14 years, 1989–2005. Acta Diabetol 47:29–33CrossRefPubMedGoogle Scholar
  6. 6.
    Fuller JH (1994) The epidemiology and prevention of diabetes. In: Vuylsteek K, Hallen M (eds) Epidemiology. IOS Press, Amsterdam, pp 140–167Google Scholar
  7. 7.
    Green A, Gale EAM, Patterson CC (1992) Incidence of childhood onset insulin-dependent diabetes mellitus: the EURODIAB ACE study. Lancet 339:905–909CrossRefPubMedGoogle Scholar
  8. 8.
    Jarosz-Chobot P, Polanska J, Szadkowska A, Kretowski A, Bandurska-Stankiewicz E, Ciechanowska M, Deja G, Mysliwiec M, Peczynska J, Rutkowska J, Sobel-Maruniak A, Fichna P, Chobot A, Rewers M (2011) Rapid increase in the incidence of type 1 diabetes in Polish children from 1989 to 2004, and predictions for 2010 to 2025. Diabetologia 54:508–515CrossRefPubMedCentralPubMedGoogle Scholar
  9. 9.
    Jarosz-Chobot P, Polanska J, Polanski A (2008) Does social-economical transformation influence the incidence of type 1 diabetes? A Polish example. Pediatr Diabetes 9:202–207CrossRefPubMedGoogle Scholar
  10. 10.
    Eurodiab, ACE Study Group (2000) Variation and trends in incidence of childhood diabetes in Europe. Lancet 335:873–876Google Scholar
  11. 11.
    Patterson CC, Gyürüs E, Rosenbauer J, Cinek O, Neu A, Schober E, Parslow RC, Joner G, Svensson J, Castell C, Bingley PJ, Schoenle E, Jarosz-Chobot P, Urbonaité B, Rothe U, Krzisnik C, Ionescu-Tirgoviste C, Weets I, Kocova M, Stipancic G, Samardzic M, de Beaufort CE, Green A, Dahlquist GG, Soltész G (2012) Trends in childhood type 1 diabetes incidence in Europe during 1989–2008: evidence of non-uniformity over time in rates of increase. Diabetologia 55:2142–2147CrossRefPubMedGoogle Scholar
  12. 12.
    Gyurus EK, Patterson C, Soltesz G, Hungarian Childhood Diabetes Epidemiology Group (2012) Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary–the rising trend continues (or peaks and highlands?). Pediatr Diabetes 13:21–25CrossRefPubMedGoogle Scholar
  13. 13.
    Skrivarhaug T, Stene LC, Drivvoll AK, Strøm H, Joner G, Norwegian Childhood Diabetes Study Group (2014) Incidence of type 1 diabetes in Norway among children aged 0–14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian childhood diabetes registry. Diabetologia 57:57–62CrossRefPubMedGoogle Scholar
  14. 14.
    Rojnic Putarek N, Ille J, Spehar Uroic A, Skrabic V, Stipancic G, Krnic N, Radica A, Marjanac I, Severinski S, Svigir A, Bogdanic A, Dumic M (2014) Incidence of type 1 diabetes mellitus in 0 to 14-yr-old children in Croatia—2004 to 2012 study. Pediatr Diabetes. doi: 10.1111/pedi.12197 PubMedGoogle Scholar
  15. 15.
    Ehehalt S, Dietz K, Willasch AM, Neu A, DIARY-Group Baden-Wuerttemberg (2012) Prediction model for the incidence and prevalence of type 1 diabetes in childhood and adolescence: evidence for a cohort-dependent increase within the next two decades in Germany. Pediatr Diabetes 13:15–20CrossRefPubMedGoogle Scholar
  16. 16.
    Spaans-Hummelink EAJM, Gusdorf LMA, Groenier KH, Brand PL, Veeze HJ, Reeser HM, Bilo HJG, Kleefstra N (2014) Increasing incidence of type 1 diabetes in children in the Netherlands: a nationwide cohort study (young DUDEs-1). Pediatric Diabetes 15(Suppl. 19):90Google Scholar
  17. 17.
    Catanzariti L, Faulks K, Moon L, Waters AM, Flack J, Craig ME (2009) Australia’s national trends in the incidence of Type 1 diabetes in 0-14-year-olds, 2000–2006. Diabet Med 26:596–601CrossRefPubMedGoogle Scholar
  18. 18.
    Tamayo T, Rosenbauer J, Wild SH, Spijkerman AM, Baan C, Forouhi NG, Herder C, Rathmann W (2014) Diabetes in Europe: an update. Diabetes Res Clin Pract 103:206–217CrossRefPubMedGoogle Scholar
  19. 19.
    Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G, EURODIAB Study Group (2009) Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study. Lancet 373:2027–2033CrossRefPubMedGoogle Scholar
  20. 20.
    Gyurus EK, Patterson C, Soltesz G (2011) Constantly rising or peaks and plateaus? Incidence of childhood type 1 diabetes in Hungary (1989–2009) [Article in Hungarian]. Orv Hetil 152:1692–1697CrossRefPubMedGoogle Scholar
  21. 21.
    Teeäär T, Liivak N, Heilman K, Kool P, Sor R, Paal M, Einberg U, Tillmann V (2010) Increasing incidence of childhood-onset type 1 diabetes mellitus among Estonian children in 1999–2006. Time trend analysis 1983–2006. Pediatr Diabetes 11:107–110CrossRefPubMedGoogle Scholar
  22. 22.
    The Diamond Study Group (2006) Incidence and trends of childhood T1DM worldwide 1990–1999. Diabet Med 23:857–866CrossRefGoogle Scholar
  23. 23.
    Radosevic B, Bukara-Radujkovic G, Miljkovic V, Pejicic S, Bratina N, Battelino T (2013) The incidence of type 1 diabetes in Republic of Srpska (Bosnia and Herzegovina) and Slovenia in the period 1998–2010. Pediatr Diabetes 14:273–279CrossRefPubMedGoogle Scholar
  24. 24.
    Bruno G, Maule M, Biggeri A, Ledda A, Mannu C, Merletti F, Songini M, Sardinian Group for Diabetes Epidemiology (2013) More than 20 years of registration of type 1 diabetes in Sardinian children: temporal variations of incidence with age, period of diagnosis, and year of birth. Diabetes 62:3542–3546CrossRefPubMedCentralPubMedGoogle Scholar
  25. 25.
    Berhan Y, Waernbaum I, Lind T, Möllsten A, Dahlquist G, Swedish Childhood Diabetes Study Group (2011) Thirty years of prospective nationwide incidence of childhood type 1 diabetes: the accelerating increase by time tends to level off in Sweden. Diabetes 60:577–581CrossRefPubMedCentralPubMedGoogle Scholar
  26. 26.
    Cinek O, Kulich M, Sumnik Z (2012) The incidence of type 1 diabetes in young Czech children stopped rising. Pediatr Diabetes 13:559–563CrossRefPubMedGoogle Scholar
  27. 27.
    TEDDY Study Group (2008) The environmental determinants of diabetes in the young (TEDDY) study. Ann N Y Acad Sci 1150:1–13CrossRefPubMedCentralGoogle Scholar
  28. 28.
    Chmiel R, Beyerlein A, Knopff A, Hummel S, Ziegler AG, Winkler C (2014) Early infant feeding and risk of developing islet autoimmunity and type 1 diabetes. Acta Diabetol. doi: 10.1007/s00592-014-0628-5
  29. 29.
    Newhook LA, Penney S, Fiander J, Dowden J (2012) Recent incidence of type 1 diabetes mellitus in children 0–14 years in Newfoundland and Labrador, Canada climbs to over 45/100,000: a retrospective time trend study. BMC Res Notes 5:62CrossRefGoogle Scholar
  30. 30.
    Eringsmark Regnéll S, Lernmark A (2013) The environment and the origins of islet autoimmunity and type 1 diabetes. Diabet Med 30:155–160CrossRefPubMedGoogle Scholar
  31. 31.
    de Goffau MC, Fuentes S, van den Bogert B, Honkanen H, de Vos WM, Welling GW, Hyöty H, Harmsen HJ (2014) Aberrant gut microbiota composition at the onset of type 1 diabetes in young children. Diabetologia 57:1569–1577CrossRefPubMedGoogle Scholar
  32. 32.
    Vaarala O (2012) Gut microbiota and type 1 diabetes. Rev Diabet Stud 9:251–259CrossRefPubMedCentralPubMedGoogle Scholar
  33. 33.
    Markle JG, Frank DN, Adeli K, von Bergen M, Danska JS (2014) Microbiome manipulation modifies sex-specific risk for autoimmunity. Gut Microbes 5(4):485–493Google Scholar
  34. 34.
    Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, Danska JS (2013) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 339:1084–1088CrossRefPubMedGoogle Scholar
  35. 35.
    Kinross JM, Darzi AW, Nicholson JK (2011) Gut microbiome-host interactions in health and disease. Genome Med 3:14CrossRefPubMedCentralPubMedGoogle Scholar

Copyright information

© Springer-Verlag Italia 2014

Authors and Affiliations

  • Agata Chobot
    • 1
    Email author
  • Joanna Polanska
    • 2
  • Grazyna Deja
    • 3
  • Przemyslawa Jarosz-Chobot
    • 3
  1. 1.Clinical Hospital No 1ZabrzePoland
  2. 2.Data Mining GroupTechnical University of SilesiaGliwicePoland
  3. 3.Department of Pediatrics, Endocrinology and DiabetologyMedical University of SilesiaKatowicePoland

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