Comparison of arterial and mixed venous blood glucose levels in hemodynamically unstable pigs: implications for location of a continuous glucose sensor
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One of several unsolved challenges in the construction of an artificial endocrine pancreas (a system for automatically adjusting the blood glucose level) is the positioning of the glucose sensor. We believe the best positioning to be either intraarterial or in a central vein. It is therefore important to know whether the glucose content in these blood locations is the same. We conducted a post hoc analysis of previously collected data from pigs exposed to gross inflammatory and circulatory stress. Paired arterial and mixed venous glucose values were compared with a mixed effects model. We found the blood glucose values from the arterial and mixed venous blood to be the same.
KeywordsArtificial endocrine pancreas Blood glucose Continuous glucose measurement Biosensors
The authors gratefully acknowledge Eirik Skogvoll (MD, PhD, Professor, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Norway and Department of Anesthesiology and Emergency Medicine, Trondheim University Hospital, Norway) for his assistance with biostatistics. We also gratefully acknowledge Erik Solligård (MD, PhD, Assistant Professor, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway) for permission to use the data.
The financial support was provided from institutional sources at the Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway. Grant # 47058400.
Conflict of interest
All authors declare that they do not have any competing financial interests.