Acta Diabetologica

, Volume 50, Issue 3, pp 459–462

A SNP in G6PC2 predicts insulin secretion in type 1 diabetes

  • Srinath Sanda
  • Shan Wei
  • Tessa Rue
  • Heather Shilling
  • Carla Greenbaum
Short Communication

DOI: 10.1007/s00592-012-0389-y

Cite this article as:
Sanda, S., Wei, S., Rue, T. et al. Acta Diabetol (2013) 50: 459. doi:10.1007/s00592-012-0389-y


We investigated whether single nucleotide polymorphisms in genes related to glucose metabolism correlate with insulin secretion in type 1 diabetes patients. A cohort of 49 type 1 diabetes patients underwent serial mixed meal tolerance tests to assess insulin secretion. Patients were genotyped for SNPs related to glucose metabolism: CDKAL1 rs7754840, G6PC2 rs560887, HHEX rs1111875, KCNJ11 rs5215. Recently diagnosed patients (<100 days) homozygous for the G allele of G6PC2 had higher area under the curve C-peptide on mixed meal tolerance tests compared to non-homozygous patients (344.8 ± 203.2 vs. 167.9 ± 131.5, p = 0.04). Other SNPs did not correlate with insulin secretion in the new onset period. In a longitudinal survival analysis, homozygosity for the minor allele (A) in G6PC2 predicted more rapid loss of insulin secretion over time. A SNP in the beta cell gene G6PC2 may correlate with preserved insulin secretion in type 1 diabetes.


Translational research Genetics Longitudinal studies 



Single nucleotide polymorphisms


Mixed meal tolerance tests


Area under the curve


Institutional review board


Polymerase chain reaction


Deoxyribonucleic acid


Genome-wide association studies

Supplementary material

592_2012_389_MOESM1_ESM.doc (28 kb)
Supplementary material 1 (DOC 27 kb)

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Srinath Sanda
    • 1
  • Shan Wei
    • 1
  • Tessa Rue
    • 2
  • Heather Shilling
    • 1
  • Carla Greenbaum
    • 1
  1. 1.Benaroya Research InstituteSeattleUSA
  2. 2.Institute of Translational Health SciencesSeattleUSA

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