Acta Diabetologica

, Volume 50, Issue 2, pp 273–276 | Cite as

The association of hs-CRP with fasting and postprandial plasma lipids in patients with type 2 diabetes is disrupted by dietary monounsaturated fatty acids

  • L. Bozzetto
  • C. De Natale
  • L. Di Capua
  • G. Della Corte
  • L. Patti
  • S. Maione
  • G. Riccardi
  • A. A. Rivellese
  • G. Annuzzi
Short Communication

Abstract

The aim of the study was to evaluate whether two dietary approaches recommended for diabetes mellitus and cardiovascular prevention—high-MUFA or complex carbohydrates/fiber—differently influence inflammation. A 4-week crossover study in 12 individuals with type 2 diabetes was performed. Fasting and postprandial hs-CRP plasma levels were not significantly different after a high-carbohydrate/high-fiber/low-glycemic index (CHO/fiber) and a high-MUFA diet. Compared with fasting, hs-CRP levels decreased significantly after the MUFA but not after the CHO/fiber meal. Triglyceride-rich lipoproteins were significantly lower after the CHO/fiber than the MUFA diet. At fasting and postprandially, hs-CRP correlated with triglyceride in whole plasma, chylomicrons, small and large VLDL after the CHO/fiber but not after the MUFA diet. In conclusion, a MUFA-rich diet and a carbohydrate/fiber-rich diet induced similar effects on plasma hs-CRP concentrations. However, these dietary approaches seem to influence hs-CRP levels through different mechanisms. i.e., direct acute postprandial effects by MUFA and triglyceride-rich lipoproteins mediated effects by CHO/fiber.

Keywords

Type 2 diabetes C-reactive protein Monounsaturated fatty acids Fiber Postprandial lipemia 

Notes

Conflict of interest

The authors have nothing to disclose.

References

  1. 1.
    Ridker PM (2007) Inflammatory biomarkers and risks of myocardial infarction, stroke, diabetes, and total mortality: implications for longevity. Nutr Rev 65:S253–S259PubMedCrossRefGoogle Scholar
  2. 2.
    Wu W, Wang M, Sun Z, Wang X, Miao J, Zheng Z (2011) The predictive value of TNF-alpha and IL-6 and the incidence of macrovascular complications in patients with type 2 diabetes. Acta Diabetol (Epub ahead of print)Google Scholar
  3. 3.
    Goldberg RB (2009) Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and embalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab 94:3171–3182PubMedCrossRefGoogle Scholar
  4. 4.
    Llauradó G, Gallart L, Tirado R, Megia A, Simón I, Caixàs A, Giménez-Palop O, Berlanga E, Vendrell J, González-Clemente JM (2011) Insulin resistance, low-grade inflammation and type 1 diabetes mellitus. Acta Diabetol (Epub ahead of print)Google Scholar
  5. 5.
    Kriketos AD, Greenfield JR, Peake PW, Furler SM, Denyer GS, Charlesworth JA, Campbell LV (2004) Inflammation, insulin resistance, and adiposity: a study of first-degree relatives of type 2 diabetic subjects. Diabetes Care 27:2033–2040PubMedCrossRefGoogle Scholar
  6. 6.
    Rivellese AA (2005) Diet and cardiovascular disease: beyond cholesterol. Nutr Metab Cardiovasc Dis 15(6):395–398PubMedCrossRefGoogle Scholar
  7. 7.
    Bortsov AV, Liese AD, Bell RA, Dabelea D, D’Agostino RB Jr, Hamman RF, Klingensmith GJ, Lawrence JM, Maahs DM, McKeown R, Marcovina SM, Thomas J, Williams DE, Mayer-Davis EJ (2011) Sugar-sweetened and diet beverage consumption is associated with cardiovascular risk factor profile in youth with type 1 diabetes. Acta Diabetol (Epub ahead of print)Google Scholar
  8. 8.
    Ma Y, Griffith JA, Chasan-Taber L, Olendzki BC, Jackson E, Stanek EJ 3rd, Li W, Pagoto SL, Hafner AR, Ockene IS (2006) Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr 83:760–766PubMedGoogle Scholar
  9. 9.
    Ajani UA, Ford ES, Mokdad AH (2004) Dietary fiber and C-reactive protein: findings from national health and nutrition examination survey data. J Nutr 134:1181–1185PubMedGoogle Scholar
  10. 10.
    Ma Y, Hebert JR, Li W, Bertone-Johnson ER, Olendzki B, Pagoto SL, Tinker L, Rosal MC, Ockene IS, Ockene JK, Griffith JA, Liu S (2008) Association between dietary fiber and markers of systemic inflammation in the women’s health initiative observational study. Nutrition 24:941–949PubMedCrossRefGoogle Scholar
  11. 11.
    North CJ, Venter CS, Jerling JC (2009) The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease. Eur J Clin Nutr 63:921–933PubMedCrossRefGoogle Scholar
  12. 12.
    Junker R, Pieke B, Schulte H, Nofer R, Neufeld M, Assmann G, Wahrburg U (2001) Changes in hemostasis during treatment of hypertriglyceridemia with a diet rich in monounsaturated and n-3 polyunsaturated fatty acids in comparison with a low-fat diet. Thromb Res 101:355–366PubMedCrossRefGoogle Scholar
  13. 13.
    Jebb SA, Lovegrove JA, Griffin BA, Frost GS, Moore CS, Chatfield MD, Bluck LJ, Williams CM, Sanders TA (2010) RISCK Study Group. Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial. Am J Clin Nutr 92(4):748–758PubMedCrossRefGoogle Scholar
  14. 14.
    Blum S, Aviram M, Ben-Amotz A, Levy Y (2006) Effect of a Mediterranean meal on postprandial carotenoids, paraoxonase activity and C-reactive protein levels. Ann Nutr Metab 50:20–24PubMedCrossRefGoogle Scholar
  15. 15.
    De Natale C, Annuzzi G, Bozzetto L, Mazzarella R, Costabile G, Ciano O, Riccardi G, Rivellese AA (2009) Effects of a plant-based high-carbohydrate/high-fiber diet versus high-monounsaturated fat/low-carbohydrate diet on postprandial lipids in type 2 diabetic patients. Diabetes Care 32:2168–2173PubMedCrossRefGoogle Scholar
  16. 16.
    Jimenez-Gomez Y, Lopez-Miranda J, Blanco-Colio LM, Marin C, Perez-Martinez P, Ruano J, Paniagua JA, Rodriguez F, Egido J, Perez-Jimenez F (2009) Olive oil and walnut breakfasts reduce the postprandial inflammatory response in mononuclear cells compared with a butter breakfast in healthy men. Atherosclerosis 204:e70–e76PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • L. Bozzetto
    • 1
  • C. De Natale
    • 1
  • L. Di Capua
    • 1
  • G. Della Corte
    • 1
  • L. Patti
    • 1
  • S. Maione
    • 1
  • G. Riccardi
    • 1
  • A. A. Rivellese
    • 1
  • G. Annuzzi
    • 1
  1. 1.Department of Clinical and Experimental MedicineFederico II UniversityNaplesItaly

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