Acta Diabetologica

, Volume 49, Issue 1, pp 9–15 | Cite as

Association between serum C-peptide levels and chronic microvascular complications in Korean type 2 diabetic patients

  • Bo-Yeon Kim
  • Chan-Hee Jung
  • Ji-Oh Mok
  • Sung-Koo Kang
  • Chul-Hee Kim
Original Article


This study evaluated the association between serum C-peptide levels and chronic vascular complications in Korean patients with type 2 diabetes. Data for 1,410 patients with type 2 diabetes were evaluated cross-sectionally. Fasting and postprandial 2-hour serum C-peptide levels were analyzed with respect to diabetic micro- and macrovascular complications. In the group of patients with lower fasting serum C-peptide quartile, the prevalences of diabetic retinopathy and neuropathy were significantly higher (P = 0.035, P < 0.001, respectively). In the group of patients with lower delta C-peptide (postprandial − fasting C-peptide) quartile, the prevalences of diabetic retinopathy, nephropathy, and neuropathy were significantly higher (P < 0.001 for all). Low delta C-peptide quartile was also associated with increased severity of retinopathy and nephropathy. The age- and sex-adjusted odds ratios (ORs) for retinopathy, neuropathy, and nephropathy in the lowest versus the highest delta C-peptide quartile were 6.45 (95% confidence interval 3.41–12.22), 3.01 (2.16–4.19), and 2.65 (1.71–4.12), respectively. After further adjustment for the duration of diabetes, type of antidiabetic therapy, mean hemoglobin A1c, body mass index, and blood pressure, the ORs were reduced to 2.83 (1.32–6.08), 1.68 (1.12–2.53), and 1.61 (1.05–2.47), respectively, but remained significant. No significant difference was observed in the prevalence of macrovascular complications with respect to fasting or delta C-peptide quartiles. These results suggest that low C-peptide level is associated with diabetic microvascular, but not macrovascular complications in patients with type 2 diabetes mellitus.


C-peptide Type 2 diabetes mellitus Microvascular complications Macrovascular complications 


Conflicts of interest

None of the authors had any conflicts of interest related to this study.

Supplementary material

592_2010_249_MOESM1_ESM.doc (36 kb)
Supplementary material 1 (DOC 36 kb)


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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Bo-Yeon Kim
    • 1
  • Chan-Hee Jung
    • 1
  • Ji-Oh Mok
    • 1
  • Sung-Koo Kang
    • 1
  • Chul-Hee Kim
    • 1
  1. 1.Division of Endocrinology and Metabolism, Department of Internal MedicineBucheon Hospital, Soonchunhyang University College of MedicineBucheonSouth Korea

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