Acta Diabetologica

, Volume 49, Issue 3, pp 185–191 | Cite as

White rice vinegar improves pancreatic beta-cell function and fatty liver in streptozotocin-induced diabetic rats

  • Xuemei Gu
  • Hai-Lu Zhao
  • Yi Sui
  • Jing Guan
  • Juliana C. N. Chan
  • Peter C. Y. Tong
Original Article


Vinegar is a traditional remedy for ailments including diabetes. This study was conducted to investigate the beneficial effects of vinegar in streptozotocin (STZ)-induced diabetic rats. STZ-induced diabetic rats were orally administered with white rice vinegar (WRV, 2 ml/kg body weight per day, n = 6) or with an equal volume of drinking water (n = 6) for 1 month. Fasting and random blood glucose was measured from tail vein samples. Body weight, 24-h food and water intake were monitored 1 week and 1 month after STZ injection. Fasting serum insulin concentrations were assayed using ELISA. Pancreatic beta- and alpha-cell proportions were measured using immunofluorescence microscopy. Periodic acid Schiff staining was performed to access glycogen contents and histological changes in liver tissues. Compared with control animals, the WRV-treated rats had less weight loss, lower fasting and random blood glucose, higher fasting serum insulin and higher beta-cell proportion. The WRV treatment also improved fatty changes and glycogen storages in the liver of STZ rats. Oral intake of WRV improved fasting hyperglycemia and body weight loss through attenuating insulin deficiency, pancreatic beta-cell deficit, and hepatic glycogen depletion and fatty changes in STZ-induced diabetic rats.


Diabetes Vinegar Insulin deficiency Streptozotocin 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Xuemei Gu
    • 1
    • 2
  • Hai-Lu Zhao
    • 2
  • Yi Sui
    • 2
  • Jing Guan
    • 2
  • Juliana C. N. Chan
    • 2
    • 3
    • 4
  • Peter C. Y. Tong
    • 3
  1. 1.Department of EndocrinologyThe First Affiliated Hospital, Wenzhou Medical CollegeWenzhouChina
  2. 2.Department of Medicine and Therapeutics, Prince of Wales HospitalThe Chinese University of Hong KongShatinHong Kong
  3. 3.Hong Kong Institute of Diabetes and ObesityThe Chinese University of Hong KongShatinChina
  4. 4.Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongShatinChina

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