Acta Diabetologica

, Volume 47, Issue 4, pp 295–300 | Cite as

Patients’ evaluation of nocturnal hypoglycaemia with GlucoDay continuous glucose monitoring in paediatric patients

  • Franco Meschi
  • Riccardo Bonfanti
  • Andrea Rigamonti
  • Frontino Giulio
  • Roseila BattaglinoEmail author
  • Matteo Viscardi
  • Alessandro Poscia
  • Giuseppe Chiumello
Original Article


A study was conducted to evaluate the accuracy of GlucoDay (A. Menarini Diagnostics) during 48 h of continuous glucose monitoring (CGMS) in type 1 diabetic adolescents and use this novel approach to assess otherwise ignored nocturnal hypoglycaemias, in relationship to intermediate-acting insulin administration timing. Twenty type 1 diabetic adolescents with poor metabolic control were selected from our out-patient department. Equal doses of intermediate insulin were administered at 19:00 and at 22:00 of the first and second night of the study, respectively. Correlation coefficient between GlucoDay and standard glucometer was 0.94; 98.3% of data fall in the A + B area of Error Grid Analysis and 1.7% in the D area. The mean error was 13.9% overall and 16.4% with blood glucose values (BGV) <75 mg/dl. The accuracy, ±15 mg/dl, was 82% for BGV <75 mg/dl and 74% for BGV >75 mg/dl. The CGMS discovered nocturnal hypoglycaemia (NH) in 12/18 patients, but no severe hypoglycaemia. During the first night, 8 asymptomatic NH episodes were found with BGV <60 mg/dl and 12 with BGV <80. During the second night, 4 asymptomatic NH episodes with BGV <60 mg/dl and 5 with BGV <80 were found. Furthermore, during the second night, the mean duration of BGV <126 mg/dl was lower than in the first night. GlucoDay is a reliable device for CGMS in paediatric patients and able to determine asymptomatic NH. Bedtime insulin injections provided safer glycaemic profiles and a lower percentage of hypoglycaemic events, representing a safer insulin administration scheme.


CGMS Hypoglycaemia Nocturnal hypoglycaemia Insulin treatment 



This study was funded by a research grant from Menarini I.F.R., Florence, Italy. We thank Alessandro Poscia, Silvia Beghin, and Alberto Maran for their expert assistance.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Franco Meschi
    • 1
  • Riccardo Bonfanti
    • 1
  • Andrea Rigamonti
    • 1
  • Frontino Giulio
    • 1
  • Roseila Battaglino
    • 1
    • 3
    Email author
  • Matteo Viscardi
    • 1
  • Alessandro Poscia
    • 2
  • Giuseppe Chiumello
    • 1
  1. 1.Paediatric Department, Scientific Institute H San RaffaeleVita-Salute UniversityMilanItaly
  2. 2.Menarini I.F.R.FlorenceItaly
  3. 3.Centro di Endocrinologia dell’Infanzia e dell’Adolescenza, Scientific Institute H San RaffaeleUniversità Vita-SaluteMilanItaly

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