Acta Diabetologica

, Volume 47, Issue 2, pp 119–124

Circulating vascular endothelial growth factor in the normo- and/or microalbuminuric patients with type 2 diabetes mellitus

  • Peter Kubisz
  • Peter Chudý
  • Ján Staško
  • Peter Galajda
  • Pavol Hollý
  • Robert Vyšehradský
  • Marián Mokáň
Original Article

Abstract

Relationship between serum vascular endothelial growth factor (VEGF) level and parameters of endothelial injury and/or dysfunction in patients with diabetes mellitus type 2 with or without microalbuminuria was investigated. Eighty-four diabetic patients were divided in two subgroups (42 each): normoalbuminuric (NAU) and microalbuminuric (MAU). Forty-two blood donors were in control group. Serum VEGF and plasma von Willebrand factor, soluble thrombomodulin, plasminogen activator inhibitor 1, thrombin-activatable fibrinolysis inhibitor (TAFI) and tissue plasminogen activator (t-PA) were measured using enzyme-linked immunosorbent assay in all subjects. VEGF was significantly higher in NAU compared to controls. The difference between MAU and controls was not statistically significant, but there was a trend toward significance. Only TAFI correlated with VEGF in MAU. An observed significant increase of serum VEGF level already in NAU suggests that serum VEGF could be a sensitive predictor of endothelial dysfunction in type 2 diabetes.

Keywords

VEGF Diabetes mellitus type 2 Endothelial dysfunction 

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Peter Kubisz
    • 1
  • Peter Chudý
    • 1
  • Ján Staško
    • 1
  • Peter Galajda
    • 2
  • Pavol Hollý
    • 1
  • Robert Vyšehradský
    • 3
  • Marián Mokáň
    • 2
  1. 1.National Center of Hemostasis and Thrombosis, Jessenius Faculty of MedicineComenius UniversityMartinSlovakia
  2. 2.Clinic of Internal Medicine 1, Jessenius Faculty of MedicineComenius UniversityMartinSlovakia
  3. 3.Clinic of Pneumophthisiology, Jessenius Faculty of MedicineComenius UniversityMartinSlovakia

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