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Acta Diabetologica

, Volume 47, Issue 1, pp 73–78 | Cite as

The geospatial relation between UV solar radiation and type 1 diabetes in Newfoundland

Original Article

Abstract

Type 1 diabetes (T1DM) has been previously associated with northern latitude and vitamin D insufficiency. This study investigates the geospatial association between average daily ultraviolet B (UVB) irradiance and T1DM across the province of Newfoundland (NL), Canada. NL has one of the highest documented incidences of T1DM worldwide. A complete list of patients diagnosed (1987–2005) with T1DM in the province of Newfoundland and Labrador (NL) was constructed using multiple sources. All places of habitation at diagnosis were ascertained. Ecological analysis using Bayesian estimation was performed employing both NASA UVB data and latitude. Correlation of T1DM to both UVB irradiation and latitude was measured. A statistically significant correlation of erythemal UVB irradiance was observed (−0.0284: 95% CI −0.0542 to −0.0096). A more significant correlation of T1DM was observed with erythemal UVB irradiance than with latitude. This study suggests that erythemal UVB radiation may be geospatially associated with the incidence of T1DM in NL.

Keywords

Type 1 diabetes Epidemiology Ecological analysis Geospatial correlation 

Notes

Acknowledgments

The authors would like to thank Dr. Andrew Lawson at the Arnold School of Public Health for reviewing our Bayesian models, and Dr. William Grant from the Sunlight, Nutrition and Health Research Center for suggesting the use of the NASA TOMS data and his expertise in atmospheric science.

References

  1. 1.
    Franoin RK (1997) Diabetes mellitus. Pediatr Rev 18:383–392Google Scholar
  2. 2.
    Gillespie KM (2006) Type 1 diabetes: pathogenesis and prevention. CMAJ 175(2):165–170PubMedGoogle Scholar
  3. 3.
    Rahman P, Jones A, Curtis J, Bartlett S, Peddle L, Fernandez BA et al (2003) The Newfoundland population: a unique resource for genetic investigation of complex diseases. Hum Mol Genet 12(Spec No 2):R167–R172CrossRefPubMedGoogle Scholar
  4. 4.
    Mannion JJ (1977) The peopling of Newfoundland: essays in historic geography. Memorial University of Newfoundland, St John’sGoogle Scholar
  5. 5.
    Statistics Canada (2001) Population censusGoogle Scholar
  6. 6.
    Tuomilehto J, Karvonen M, Pitkaniemi J, Virtala E, Kohtamaki K, Toivanen L et al (1999) Record-high incidence of Type I (insulin-dependent) diabetes mellitus in Finnish children. The Finnish childhood Type I diabetes registry group. Diabetologia 42(6):655–660CrossRefPubMedGoogle Scholar
  7. 7.
    Karvonen M, Viik-Kajander M, Moltchanova E, Libman I, LaPorte R, Tuomilehto J (2000) Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care 23(10):1516–1526CrossRefPubMedGoogle Scholar
  8. 8.
    Newhook LA, Grant M, Sloka S, Hoque M, Paterson AD, Hagerty D et al (2008) Very high and increasing incidence of type 1 diabetes mellitus in Newfoundland and Labrador, Canada. Pediatr Diabetes 9(3 Pt 2):62–68CrossRefPubMedGoogle Scholar
  9. 9.
    Onkamo P, Vaananen S, Karvonen M, Tuomilehto J (1999) Worldwide increase in incidence of type 1 diabetes: the analysis of the data on published incidence trends. Diabetologia 42:1395–1403CrossRefPubMedGoogle Scholar
  10. 10.
    Karvonen M, Tuomilehto J, Libman I, LaPorte R (1993) A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus World Health Organization Diamond Project Group. Diabetologia 36(10):883–892CrossRefPubMedGoogle Scholar
  11. 11.
    Diabetes Epidemiology Research International Group (1988) Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes 37(8):1113–1119CrossRefGoogle Scholar
  12. 12.
    Yang Z, Wang K, Li T, Sun W, Li Y, Chang YF et al (1998) Childhood diabetes in China enormous variation by place and ethnic group. Diabetes Care 21(4):525–529CrossRefPubMedGoogle Scholar
  13. 13.
    Staples JA, Ponsonby AL, Lim LL, McMichael AJ (2003) Ecologic analysis of some immune-related disorders, including type 1 diabetes, in Australia: latitude, regional ultraviolet radiation, and disease prevalence. Environ Health Perspect 111(4):518–523PubMedGoogle Scholar
  14. 14.
    Webb AR, Holick MF (1988) The role of sunlight in the cutaneous production of vitamin D3. Annu Rev Nutr 8:375–399CrossRefPubMedGoogle Scholar
  15. 15.
    Webb AR, Kline L, Holick MF (1988) Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 67(2):373–378CrossRefPubMedGoogle Scholar
  16. 16.
    Hypponen E, Laara E, Reunanen A, Jarvelin MR, Virtanen SM (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358(9292):1500–1503CrossRefPubMedGoogle Scholar
  17. 17.
    The EURODIAB Substudy 2 Study Group (1999) Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. Diabetologia 42(1):51–54CrossRefGoogle Scholar
  18. 18.
    Stene LC, Ulriksen J, Magnus P, Joner G (2000) Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia 43(9):1093–1098CrossRefPubMedGoogle Scholar
  19. 19.
    Sloka S, Grant M, Newhook LA (2008) Time series analysis of ultraviolet B radiation and type 1 diabetes in Newfoundland. Pediatr Diabetes 9(2):81–86CrossRefPubMedGoogle Scholar
  20. 20.
    LaPorte R, McCarty D, Bruno G, Tajima N, Baba S (1993) Counting diabetes in the next millennium. Application of capture–recapture technology. Diabetes Care 16(2):528–534CrossRefPubMedGoogle Scholar
  21. 21.
    NL Statistics Agency GoN (2003) Newfoundland and Labrador Statistics Agency. Provincial Government of NLGoogle Scholar
  22. 22.
    Bear JC, Nemec TF, Kennedy JC, Marshall WH, Power AA, Kolonel VM et al (1987) Persistent genetic isolation in outport Newfoundland. Am J Med Genet 27(4):807–830CrossRefPubMedGoogle Scholar
  23. 23.
    Martin LJ, Crawford MH, Koertvelyessy T, Keeping D, Collins M, Huntsman R (2000) The population structure of ten Newfoundland outports. Hum Biol 72(6):997–1016PubMedGoogle Scholar
  24. 24.
    Mollie A, Richardson S (1991) Empirical Bayes estimates of cancer mortality rates using spatial models. Stat Med 10(1):95–112CrossRefPubMedGoogle Scholar
  25. 25.
    Besag J (1974) Spatial interaction and the statistical analysis of lattice system. J R Stat Soc B 36:192–236Google Scholar
  26. 26.
    Gilks WR, Clayton DG, Spiegelhalter DJ (1993) Modelling complexity: applications of Gibbs sampling in medicine. J R Stat Soc B 55:39–102Google Scholar
  27. 27.
    Bernardinelli L, Montomoli C (1992) Empirical Bayes versus fully Bayesian analysis of geographical variation in disease risk. Stat Med 11(8):983–1007CrossRefPubMedGoogle Scholar
  28. 28.
    Clayton D, Kaldor J (1987) Empirical Bayes estimates of age-standardized relative risks for use in disease mapping. Biometrics 43(3):671–681CrossRefPubMedGoogle Scholar
  29. 29.
    Besag J, York J, Mollie A (1991) Bayesian image restoration with two applications in spatial statistics. Ann Inst Stat Math 43:1–59CrossRefGoogle Scholar
  30. 30.
    Spiegelhalter DJ, Thomas A, Best NG, Gilks WR (1996) BUGS: Bayesian inference using Gibbs sampling, Version 0.5. Medical Research Council Biostatistics Unit, CambridgeGoogle Scholar
  31. 31.
    Sloka JS, Pryse-Phillips WE, Stefanelli M (2008) The relation of ultraviolet radiation and multiple sclerosis in Newfoundland. Can J Neurol Sci 35(1):69–74PubMedGoogle Scholar
  32. 32.
    Clayton DG, Bernardinelli L (1992) Bayesian methods for mapping disease risk. In: Elliott P, Cuzick J, English DR, Stern R (eds) Geographical and environmental epidemiology: methods for small-area studies. Oxford University Press, OxfordGoogle Scholar
  33. 33.
    Sloka JS, Crowley M, Fernandez B, Maroun F (2006) Bayesian small area cluster analysis of neural tube defects in Newfoundland. Can J Public Health 97(5):393–397PubMedGoogle Scholar
  34. 34.
    Richardson S, Monfort C, Green M, Draper G, Muirhead C (1995) Spatial variation of natural radiation and childhood leukaemia incidence in Great Britain. Stat Med 14(21–22):2487–2501CrossRefPubMedGoogle Scholar
  35. 35.
    Bernardinelli L, Pascutto C, Montomoli C, Gilks W (2000) Investigating the genetic association between diabetes and malaria: an application of Bayesian ecological regression models with errors in covariates. In: Elliott P, Wakefield J, Best N, Briggs D (eds) Spatial epidemiolgy: methods and applications. Oxford University Press, Oxford, pp 286–301Google Scholar
  36. 36.
    Bernardinelli L, Pascutto C, Montomoli C, Komakec J, Gilks W (1999) Ecological regression with errors in covariates. In: Lawson A, Boehning D, Lasaffree E, Biggeri A, Viel J, Bertolline R (eds) Disease mapping and risk assessment for public health. Wiley, Chichester, pp 329–348Google Scholar
  37. 37.
    Tukiendorf A (2001) An ecological analysis of leukemia incidence around the highest 137Cs concentration in Poland. Cancer Causes Control 12(7):653–659CrossRefPubMedGoogle Scholar
  38. 38.
    Cardwell CR, Carson DJ, Patterson CC (2006) Higher incidence of childhood-onset type 1 diabetes mellitus in remote areas: a UK regional small-area analysis. Diabetologia 49(9):2074–2077CrossRefPubMedGoogle Scholar
  39. 39.
    Gale CR, Martyn CN (1995) Migrant studies in multiple sclerosis. Prog Neurobiol 47(4–5):425–448CrossRefPubMedGoogle Scholar
  40. 40.
    Macpherson A, Macpherson J (2006) The natural environment of Newfoundland, past and present. Department of Geography, Memorial University of Newfoundland, St John’sGoogle Scholar

Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of NeurologyMemorial University of NewfoundlandSt John’sCanada
  2. 2.Department of PediatricsMemorial University of NewfoundlandSt John’sCanada

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