Acta Diabetologica

, Volume 46, Issue 3, pp 239–242

Low human paraoxonase predicts cardiovascular events in Japanese patients with type 2 diabetes

  • Yukio Ikeda
  • Mari Inoue
  • Tadashi Suehiro
  • Kaoru Arii
  • Yoshitaka Kumon
  • Kozo Hashimoto
Short Communication

DOI: 10.1007/s00592-008-0066-3

Cite this article as:
Ikeda, Y., Inoue, M., Suehiro, T. et al. Acta Diabetol (2009) 46: 239. doi:10.1007/s00592-008-0066-3

Abstract

Human serum paraoxonase (PON1) is associated with HDL and inhibits oxidative modification of LDL. PON1 enzymatic activity has been shown to decrease in diabetic patients; however, the effect of PON1 status on long-term outcome has not been reported. In this study, we examined the association between baseline PON1 status and the development of cardiovascular disease (CVD) during 10 years of follow-up in 88 type 2 diabetic patients whose enzymatic activities, concentrations, and genetic polymorphisms of PON1 had been determined. A total of 20 CVD events were recorded during the follow-up period. Using Kaplan–Meier survival curves, we found a significantly increased incidence of CVD in patients with a lower concentration or paraoxonase activity of PON1 than each median value (log-rank 7.460; < 0.01, and log-rank 4.187; < 0.05, respectively). By Cox regression analysis, both concentration and paraoxonase activity were significantly associated with the development of CVD, even after correction for gender, age, and preexisting CVD (P < 0.05). Low concentration and enzymatic activity of PON1 may be an independent predictor of cardiovascular events in diabetic patients.

Keywords

Serum paraoxonase PON1 Cardiovascular disease Type 2 diabetes 

Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Yukio Ikeda
    • 1
  • Mari Inoue
    • 1
  • Tadashi Suehiro
    • 1
  • Kaoru Arii
    • 1
  • Yoshitaka Kumon
    • 2
  • Kozo Hashimoto
    • 1
  1. 1.Department of Endocrinology, Metabolism and Nephrology, Kochi Medical SchoolKochi UniversityNankoku, KochiJapan
  2. 2.Department of Laboratory Medicine, Kochi Medical SchoolKochi UniversityNankokuJapan

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