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Acta Diabetologica

, Volume 45, Issue 2, pp 83–85 | Cite as

Comparison of capillary blood ketone measurement by electrochemical method and urinary ketone in treatment of diabetic ketosis and ketoacidosis in children

  • Serap TuranEmail author
  • Anjumanara Omar
  • Abdullah Bereket
Original Article

Abstract

We aimed to compare the recent practical method of capillary β-hydroxy butyrate (βOHB) measurement with the widely used urinary ketone measurement in monitoring metabolic status of the patient during treatment of diabetic ketoacidosis (DKA) and diabetic ketosis (DK). Patients with DKA and DK admitted to the hospital were followed with simultaneous measurements of capillary βOHB by electrochemical method (Medisense Optium, Abbott), and urinary ketone by semi-quantitative method. Blood gases were measured in 2–4 h intervals. Fourteen patients with DKA/DK (7 males and 7 females, age: 9.2 ± 4.2 years) were included with 50 simultaneous measurements of capillary and urinary ketone. No correlation was detected between urinary ketone and blood pH (P = 0.06) and HCO3 (P = 0.79), whereas a significant negative correlation was found between capillary βOHB and blood pH (r = −0.41, P < 0.05) and HCO3 (r = −0.35, P < 0.05). Capillary βOHB and urinary ketone levels did not correlate at the beginning and 3.3 ± 1.4 h after treatment, but did correlate in the third samples taken 7.8 ± 2.0 h after treatment (r = 0.8, P < 0.05). Capillary βOHB levels show good correlation with the degree of acidosis (pH and HCO3). Capillary βOHB measurement is more sensitive than urinary ketone measurement in reflecting the patient’s metabolic status and improvement during treatment.

Keywords

Diabetic ketoacidosis Type 1 diabetes mellitus β-hydroxy butyrate Urinary ketone Ketone measurement 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • Serap Turan
    • 1
    • 2
    Email author
  • Anjumanara Omar
    • 1
  • Abdullah Bereket
    • 1
  1. 1.Faculty of Medicine, Department of Pediatric EndocrinologyMarmara UniversityIstanbulTurkey
  2. 2.Cocuk Sagligi ve HastaliklariMarmara Universitesi Tip Fakultesi HastanesiIstanbulTurkey

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