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Acta Diabetologica

, Volume 43, Issue 4, pp 93–98 | Cite as

Lack of association between the fatty acid binding protein 2 (FABP2) polymorphism with obesity and insulin resistance in two aboriginal populations from Chile

  • F. Pérez-Bravo
  • M. Fuentes
  • B. Angel
  • H. Sanchez
  • E. Carrasco
  • J. L. Santos
  • L. Lera
  • C. Albala
ORIGINAL

Abstract

The aim of this study was to assess the frequency of fatty acid binding protein 2 (FABP2) Ala54Thr genetic polymorphism and to evaluate its association with obesity and insulin resistance in Chilean aboriginal populations. A sample of 96 urban Aymara and 111 urban Mapuche subjects aged 20–80 years were recruited for this cross-sectional study. Glucose, insulin and lipid profile were measured in fasting plasma samples. Insulin resistance was estimated through the HOMA-IR model. FABP2 Ala54Thr genotypes were determined by PCR followed by RFLP analysis. The allele frequency of Thr54 variant was estimated as 18.2% in Aymara subjects, which is one of the lowest reported to date. The corresponding frequency in Mapuche subjects was 31.9% (p<0.002). Regarding genotype–phenotype associations, no significant differences were found in any of the anthropometric or metabolic variables according to Ala54Thr genotypes. After adjustment by BMI and metabolic variables through a logistic regression analysis, the association of the FABP2 polymorphism with ethnic group persisted (Mapuche group: OR=2.37, 95% CI 1.319–4.277, p=0.004) It is unlikely that Ala54Thr polymorphism of the FABP2 gene plays a relevant role in obesity and insulin resistance in Chilean ethnic groups.

Key words

BMI Genotype Fatty acids Ethnic background Amerindians 

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Copyright information

© Springer-Verlag Italia 2006

Authors and Affiliations

  • F. Pérez-Bravo
    • 1
  • M. Fuentes
    • 1
  • B. Angel
    • 1
  • H. Sanchez
    • 1
  • E. Carrasco
    • 2
  • J. L. Santos
    • 1
  • L. Lera
    • 1
  • C. Albala
    • 1
  1. 1.Department of Public Nutrition Genetic Epidemiology UnitInstitute of Nutrition and Food Technology (INTA) University of ChileSantiagoChile
  2. 2.Department of Diabetes San Juan de DiosHospital Faculty of Medicine, University of ChileSantiagoChile

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