Rifampin and tobramycin combination with PMMA antibiotic cement

  • Elive F. Likine
  • David SeligsonEmail author


Rifampin is a powerful antibiotic used in the treatment of biofilm-forming bacteria with studies supporting its use in PMMA cement. However, it has not been widely accepted for its use in PMMA cement due to a perception that it is unable to solidify in a timely manner. The technique described consists of ratio of aminoglycoside and rifampin that reduces time to solidification to approximately 15–20 min.


Tobramycin Rifampin Polymethylmethacrylate PMMA Antibiotic cement 


Compliance with ethical standards

Conflict of interest

No authors involved in this study have any conflict of interests pertaining to this study in particular. Please contact corresponding author with all other questions, comments and/or concerns.


  1. 1.
    Rose WE, Otto DP, Aucamp ME, Miller Z, De Villiers MM (2015) Prevention of biofilm formation by methacrylate-based copolymer films loaded with rifampin, clarithromycin, doxycycline alone or in combination. Pharm Res 32(1):61–73CrossRefGoogle Scholar
  2. 2.
    Sanchez CJ, Shiels SM, Tennent DJ, Hardy SK, Murray CK, Wenke JC (2015) Rifamycin derivatives are effective against Staphylococcal biofilms in vitro and elutable from PMMA. Clin Orthop Relat Res 473:2874–2884CrossRefGoogle Scholar
  3. 3.
    Hake ME, Hake HY, Hak DJ, Stahel PF, Hamerberg M, Mauffrey C (2015) Local antibiotic therapy strategies in orthopedic trauma: practical tips and tricks and review of literature. Injury 46:1447–1456CrossRefGoogle Scholar
  4. 4.
    Inzana JA, Schwarz EM, Kates SL, Awad HA (2016) Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials 81:58–71. CrossRefGoogle Scholar
  5. 5.
    De Palma L, Greco F, Ciarpaglini C, Caneva C (1982) The mechanical properties of ‘cement-antibiotic’ mixtures. Ital J Orthop Traumatol 8:461–467Google Scholar
  6. 6.
    Arora M, Chan EK, Gupta S, Diwan AD (2013) Polymethylmethacrylate bone cements and additives: a review of the literature. World J Orthop 4(2):67–74. CrossRefGoogle Scholar
  7. 7.
    Madanagopal SG, Seligson D, Roberts GS (2014) The antibiotic cement nail for infection after tibial nailing. Orthopedics 27(7):709–712Google Scholar
  8. 8.
    Kim JW, Cuellar DO, Hao J, Seligson D, Mauffrey C (2014) Custom-made antibiotic cement nails: a comparative study of different fabrication techniques. Injury 45:1179–1185CrossRefGoogle Scholar

Copyright information

© Springer-Verlag France SAS, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Indiana University School of MedicineIndianapolisUSA
  2. 2.Department of OrthopaedicsUniversity Hospital LouisvilleLouisvilleUSA

Personalised recommendations