Rifampin and tobramycin combination with PMMA antibiotic cement
Rifampin is a powerful antibiotic used in the treatment of biofilm-forming bacteria with studies supporting its use in PMMA cement. However, it has not been widely accepted for its use in PMMA cement due to a perception that it is unable to solidify in a timely manner. The technique described consists of ratio of aminoglycoside and rifampin that reduces time to solidification to approximately 15–20 min.
KeywordsTobramycin Rifampin Polymethylmethacrylate PMMA Antibiotic cement
Compliance with ethical standards
Conflict of interest
No authors involved in this study have any conflict of interests pertaining to this study in particular. Please contact corresponding author with all other questions, comments and/or concerns.
- 4.Inzana JA, Schwarz EM, Kates SL, Awad HA (2016) Biomaterials approaches to treating implant-associated osteomyelitis. Biomaterials 81:58–71. https://doi.org/10.1016/j.biomaterials.2015.12.012 CrossRefGoogle Scholar
- 5.De Palma L, Greco F, Ciarpaglini C, Caneva C (1982) The mechanical properties of ‘cement-antibiotic’ mixtures. Ital J Orthop Traumatol 8:461–467Google Scholar
- 7.Madanagopal SG, Seligson D, Roberts GS (2014) The antibiotic cement nail for infection after tibial nailing. Orthopedics 27(7):709–712Google Scholar