Calcitonin effects on shoulder adhesive capsulitis

  • Alireza Rouhani
  • Mohsen Mardani-KiviEmail author
  • Mohammadreza Bazavar
  • Mahmood Barzgar
  • Ali Tabrizi
  • Keyvan Hashemi-Motlagh
  • Khashayar Saheb-Ekhtiari
Original Article • SHOULDER - TRAUMA



Adhesive capsulitis (frozen shoulder) is a relatively prevalent disease of shoulder and affects soft tissue of glenohumeral joint. Signs include painful restricted motion and disability of the patient in daily activities. Calcitonin is a thyroid hormone, and its effectiveness has been demonstrated in painful conditions. The presents study aims to evaluate the effect of calcitonin in treating shoulder adhesive capsulitis.


This double-blinded randomized clinical trial was conducted on 64 patients suffering from shoulder adhesive capsulitis. The intervention and control groups were given intranasal calcitonin and placebo for 6 weeks, respectively. For both groups, physiotherapy and non-steroidal anti-inflammatory drugs were administered correspondingly. The patients were evaluated pre- and post-treatment for shoulder pain and shoulder range of motion (ROM). Shoulder functional outcome (secondary outcome) was evaluated using Disability of Arm, Shoulder, and Hand, Shoulder Pain and Disability Index, and Health Assessment Questionnaire disability criteria.


The mean age of patients in calcitonin and control group was 52.4 ± 4.6 and 53.2 ± 4.9, respectively. Demographic characteristics and pre-treatment scores were similar in both groups (all P > 0.05). In post-treatment follow-up, shoulder pain, ROM, and the patients’ functional scores were significantly improved in both groups (P < 0.001); however, the improvement in calcitonin group was more effective than that of placebo group.


Intranasal calcitonin spray could be an additional safe alternative in shoulder adhesive capsulitis with regard to the efficiency in alleviating pain and improving functional outcome.

Level of evidence



Shoulder Adhesive capsulitis Calcitonin Range of motion Physiotherapy 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest to disclose.

Ethical approval

Tabriz University of Medical Sciences Ethics Committee approved the study, and it was registered on the Iranian Registry of Clinical Trials (IRCT No.: IRCT2013080414271n1).


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Copyright information

© Springer-Verlag France 2016

Authors and Affiliations

  1. 1.Orthopedic Department of Tabriz University of Medical SciencesTabrizIran
  2. 2.Poursina HospitalOrthopedic Department of Guilan University of Medical SciencesRashtIran

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