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Systematic review and meta-analysis on steroid injection therapy for de Quervain’s tenosynovitis in adults

  • Muhammad Omer Ashraf
  • V. G. Devadoss
General Review

Abstract

Background

de Quervain’s tenosynovitis is a painful condition of the wrist which leads to difficulties in performing activities of daily living.

Aims

This systematic review was conducted to examine the effectiveness of steroid injection therapy as compared to splinting for treatment of de Quervain’s tenosynovitis in adults.

Methods

The following databases were searched for relevant studies, MEDLINE, EMBASE, CINAHL, AMED and PsycINFO (via NHS Evidence), and Cochrane Library (via Cochrane Collaboration). Synonyms and free texts were used to locate studies. The reference lists of articles were checked for related papers. Hand searching was performed for important relevant journals. All searches found 89 studies, out of which 14 were relevant. Two studies were selected according to the inclusion criteria of the systematic review. Data were extracted and analysed for the two selected randomised trials using a fixed effect model at 95 % confidence intervals.

Results

The meta-analysis demonstrated that the total effect estimate was 3 with a narrow 95 % confidence interval (1.89, 4.77). z score for overall effect was 4.66 which was highly significant (p < 0.01). Moderate heterogeneity with I-square test was found to be 64 % but was not significant (p > 0.05). Number needed to treat was 2, which showed that for every two persons treated with steroid injections, one person gets the benefit.

Conclusion

Steroid injection is an effective form of conservative management for de Quervain’s disease although more research is needed to establish the full benefits of the treatment.

Keywords

de Quervain’s disease Tenosynovitis Steroid injections Systematic review 

Notes

Conflict of interest

Each author certifies that he has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

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Copyright information

© Springer-Verlag France 2013

Authors and Affiliations

  1. 1.The Royal Oldham HospitalOldhamUK
  2. 2.Rochdale InfirmaryRochdaleUK

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