Abstract
Extraskeletal osteosarcoma is a rare soft tissue neoplasm arising from mesenchymal elements with characteristic production of osteoid. These tumours are known to have high rate of distant metastasis and dismal prognosis. We present a rare case of extraskeletal osteosarcoma arising in medial aspect of knee joint with synchronous inguinal node and soft tissue metastasis. The patient was initially diagnosed as myositis ossificans at an outside institute and excised without prior imaging or biopsy. The patient presented to our hospital with recurrent lesion along with palpable inguinal lymph nodes and soft tissue metastasis in thigh. The patient underwent neoadjuvant chemotherapy and wide excision of the primary lesion, soft tissue metastasis and complete groin node dissection. We also discuss the importance of PET scan and intra-operative ultrasonography in the management of these lesions.
References
Sordillio PP, Hajdu SI, Magill GB, Golbey RB (1983) Extraosseous osteogenic sarcoma. Cancer 51:727–734
Wilson H (1941) Extraskeletal ossifying tumours. Ann Surg 118:95–112
Allan CJ, Soule EH (1971) Osteogenic sarcoma of the somatic soft tissue: clinicopathologic study of 26 cases and review of literature. Cancer 27:1121–1133
Chung EB, Enzinger FM (1987) Extraskeletal osteosarcoma. Cancer 60:1132–1142
Bane BL, Evans HL, Ro JY, Carrasco CH, Grignon DJ (1990) Extraskeletal osteosarcoma: a clinicopathologic review of 26 cases. Cancer 66:2762–2770
Lee JSY, Fetsch JF, Wasdhal DA, Lee BP, Pritchard DJ, Nascimento AG (1995) A review of 40 patients of extraskeletal osteosarcoma. Cancer 76:2253–2259
Hofer SO, Molema G, Hermens RA, Wanebo HJ, Reichner JS, Hoekstra HJ (1999) The effect of surgical wound healing on tumour development. Eur J Surg Oncol 25:231–243
Rougraff BT, Aboulafia A, Biermann JS, Healey J (2009) Biopsy of soft tissue masses. Evidence based medicine for the Musculoskeletal Tumour Society. Clin Orthop Relat Res 467:2783–2791
Lee WJ, Lee DW, Chang SE, Lee MW, Choi JH, Moon KC, Koh JK (2008) Cutaneous metastasis of extraskeletal osteosarcoma arising in the mediastinum. Am J Dermatopathol 30:629–631
Kelkar G, Moiyadi AV, Kane SV (2010) Extraskeletal osteosarcoma of the chest wall with delayed metastasis to the sphenoid. Indian J Cancer 47:82–84
Tateishi U, Yamaguchi U, Sekhi K, Terauchi T, Arai Y, Kim EE (2007) Bone and soft tissue sarcoma: preoperative staging with fluorine 18 fluorodeoxyglucose PET/CT and conventional imaging. Radiology 245:839–847
Tateishi U, Yamaguchi U, Terauchi T, Maeda T, Moriyama N, Arai Y et al (2005) Extraskeletal osteosarcoma: extensive tumour thrombus on fused PET-CT images. Ann Nucl Med 19:729–732
Bajpai J, Kumar R, Sreenivas V, Sharma MC, Khan SA, Rastogi S et al (2011) Prediction of chemotherapy response by PET CT in osteosarcoma: correlation with histologic necrosis. J Pediatr Hematol Oncol 33:e271–e278
Herrmann K, Benz MR, Czernin J, Allen-Auerbach MS, Tap WD, Dry SM et al (2012) 18-FDG-PET/CT imaging as an early survival predictor in patients with primary high grade soft tissue sarcoma undergoing neoadjuvant therapy. Clin Cancer Res 18:2024–2031
Tateishi U, Morita S, Taquri M, Shizukuishi K, Minamimoto R, Kawaguchi M et al (2010) A meta-analysis of (18) F-Fluoride positron emission tomography for assessment of metastatic bone tumour. Ann Nucl Med 24:523–531
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Each author certifies that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article. Each author certifies that all investigations were conducted inconformity with ethical principles of research.
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Gulia, A., Puri, A., Jain, S. et al. Extraskeletal osteosarcoma with synchronous regional lymph node and soft tissue metastasis: a rare presentation of an uncommon tumour. Eur J Orthop Surg Traumatol 23 (Suppl 2), 317–321 (2013). https://doi.org/10.1007/s00590-012-1097-6
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DOI: https://doi.org/10.1007/s00590-012-1097-6