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European Spine Journal

, Volume 10, Supplement 2, pp S122–S131 | Cite as

Demineralized bone matrix, bone morphogenetic proteins, and animal models of spine fusion: an overview

  •  H. Sandhu
  •  S. Khan
  •  D. Suh
  •  S. Boden
Original Paper

Abstract.

Preclinical investigations on the use of bone morphogenetic proteins (BMP) in the spine have yielded promising results. This has led to the preliminary introduction of these growth factors in controlled clinical trials. Initial data made available suggest that these differentiating factors will play a major role in the treatment of spinal disorders in the future. This article reviews key preclinical studies and their results that formed the basis for introduction into clinical trials. Non-primate and non-human primate models of spine fusion with BMP are reviewed objectively, and important issues regarding carrier, dose, and site of implantation are discussed. Finally, exciting new gene therapy research is discussed, with comments made on its applicability for the future.

Recombinant bone morphogenetic proteins Non-primate models Non-human primate models Delivery vehicles Gene therapy models 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  •  H. Sandhu
    • 1
  •  S. Khan
    • 1
  •  D. Suh
    • 2
  •  S. Boden
    • 3
  1. 1.Spinal Surgical Service, Hospital for Special Surgery, Weill Medical College of Cornell University, 535 East 70th Street, New York, NY 10021, USA
  2. 2.Department of Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
  3. 3.Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA

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