European Spine Journal

, Volume 10, Supplement 2, pp S102–S109

Factors stimulating bone formation

  • Martin Lind
  • Cody Bünger
Original Article

DOI: 10.1007/s005860100269

Cite this article as:
Lind, M. & Bünger, C. Eur Spine J (2001) 10(Suppl 2): S102. doi:10.1007/s005860100269


The aim of this review is to describe major approaches for stimulating bone healing and to review other factors affecting bone healing. Spinal bone fusion after surgery is a demanding process requiring optimal conditions for clinical success. Bone formation and healing can be enhanced through various methods. Experimental studies have revealed an array of stimulative measures. These include biochemical stimulation by use of hormones and growth factors, physical stimulation through mechanical and electromagnetic measures, and bone grafting by use of bone tissue or bone substitutes. Newer biological techniques such as stem cell transplantation and gene therapy can also be used to stimulate bone healing. Apart from bone transplantation, clinical experience with the many stimulation modalities is limited. Possible areas for clinical use of these novel methods are discussed.

Bone healing Bone graft Growth factors Stimulation Stem cells Gene therapy 

Copyright information

© Springer-Verlag 2001

Authors and Affiliations

  • Martin Lind
    • 1
  • Cody Bünger
    • 1
  1. 1.Orthopaedic Research Laboratory, Nørrebrogade 44 blg 1A, University Hospital of Aarhus, 8000 Aarhus C, Denmark

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