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Patient-rated outcome after atlantoaxial (C1-C2) fusion: more than a decade of evaluation of 2-year outcomes in 126 patients

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Abstract

Introduction

Various surgical techniques have been introduced for atlantoaxial (C1-C2) fusion, the most common being Magerl’s (transarticular) or the Harms/Goel screw fixation. Common indications include degenerative osteoarthritis (OA), trauma or rheumatoid arthritis (RA). Only few, small studies have evaluated patient-reported outcomes after C1-C2 fusion. We investigated 2-year outcomes in a large series of consecutive patients undergoing isolated C1-C2 fusion.

Methods

We analysed prospectively collected data (2005–2016) from our Spine outcomes database, collected within the framework of EUROSPINE's Spine Tango Registry. It included 126 patients (34 (27%) men, 92 (73%) women; mean (SD) age 67 ± 19 y) who had undergone first-time isolated C1-C2 fusion (61% Magerl, 39% Harms(-Goel)) at least 2 years ago for OA (83 (66%)), RA (20 (16%)), fracture (15 (12%)) or other (8 (6%)). Patients completed the multidimensional Core Outcome Measures Index (COMI; 0–10) and various single item outcomes.

Results

Questionnaires were returned by 118/126 (94%) patients, 2 years post-operative. Mean COMI scores showed a significant reduction from baseline: 6.9 ± 2.4 to 2.7 ± 2.5 (p < 0.0001). Overall, 75% patients achieved the MCIC of ≥ 2.2 points reduction in COMI and 88% reported a good global outcome. 91% patients were satisfied/very satisfied with their care. Self-reported complications were declared by 16% patients and further surgery at the same segment, by 2.5%.

Conclusion

In this large series with almost complete follow-up, C1-C2 fusion showed extremely good results. Despite the complexity of the intervention, outcomes surpassed those typically reported for simple procedures such as ACDF and lumbar discectomy, suggesting reservations about the procedure should perhaps be reviewed.

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Acknowledgements

We thank all the patients of the Schulthess Klinik who have contributed data to our in-house registry. We thank Dave O’Riordan, Gordana Balaban, Julian Amacker, Kirsten Clift, Selina Nauer, Sara Preziosa, Stéphanie Dosch, Riccardo Curatolo and Dorian Braun for the administration of the Spine Tango Surgery and Patient Self-Assessment forms.

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Authors and Affiliations

  1. Department of Spine Surgery and Neurosurgery, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland

    F. S. Kleinstück, T. F. Fekete, M. Loibl, D. Jeszenszky, D. Haschtmann & F. Porchet

  2. Spine Center Division, Department of Teaching, Research and Development, Schulthess Klinik, Lengghalde 2, 8008, Zurich, Switzerland

    A. F. Mannion

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  1. F. S. Kleinstück
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Correspondence to T. F. Fekete.

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Kleinstück, F.S., Fekete, T.F., Loibl, M. et al. Patient-rated outcome after atlantoaxial (C1-C2) fusion: more than a decade of evaluation of 2-year outcomes in 126 patients. Eur Spine J 30, 3620–3630 (2021). https://doi.org/10.1007/s00586-021-06959-1

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