Inflammatory mediators and the risk of falls among older women with acute low back pain: data from Back Complaints in the Elders (BACE)—Brazil

  • Bárbara Zille de QueirozEmail author
  • Nayza Maciel de Britto Rosa
  • Daniele Sirineu Pereira
  • Renata Antunes Lopes
  • Amanda Aparecida Oliveira Leopoldino
  • Ronaldo Luiz Thomasini
  • Diogo Carvalho Felício
  • Lygia Paccini Lustosa
  • Leani Souza Máximo Pereira
Original Article



To investigate the association between plasma levels of inflammatory cytokines (interleukin [IL]-1-β, IL-6, tumor necrosis factor [TNF]-α, and the soluble TNF receptor 1 [sTNF-R1]), disability, and risk of falls in older women with acute low back pain (LBP).


This cross-sectional study comprised a subsample of older women from the Back Complaints in the Elders international cohort study. Plasma levels of IL-1-β, IL-6, TNF-α, and sTNF-R1 were measured using enzyme-linked immunosorbent assays. Pain was assessed using the Numerical Pain Scale and McGill Pain Questionnaire, while disability was measured using the Roland Morris Questionnaire and gait speed. Risk of falls was estimated using the Physiological Profile Assessment. Linear regression model was used to verify the association between independent variables and fall risk.


One hundred and ten women (aged 69.97 ± 5.5 years) with acute LBP were included. The regression model showed an association between the risk of falls and IL-6 levels, pain, gait speed, and years of education. It also explained 21.2% of risk of falls variance. The model equation was: fall risk = 1.28 + (0.19 IL-6) + (0.02 quality of pain) + (− 0.71 gait speed) + (−0 .17 educational level).


This study showed an association between risk of falls and IL-6, pain, gait speed, and educational level in older women with LBP.

Graphic abstract

These slides can be retrieved under Electronic Supplementary Material.


Aging BACE Cytokines Disability Fall risk Low back pain 



This study was funded by the National Council for Scientific and Technological Development, Brazil (152014/2016–0).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

586_2019_6168_MOESM1_ESM.pptx (209 kb)
Supplementary file1 (PPTX 209 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Bárbara Zille de Queiroz
    • 1
    Email author
  • Nayza Maciel de Britto Rosa
    • 1
  • Daniele Sirineu Pereira
    • 2
  • Renata Antunes Lopes
    • 1
  • Amanda Aparecida Oliveira Leopoldino
    • 1
  • Ronaldo Luiz Thomasini
    • 3
  • Diogo Carvalho Felício
    • 1
  • Lygia Paccini Lustosa
    • 1
  • Leani Souza Máximo Pereira
    • 1
  1. 1.Department of Physical Therapy, Post-Graduate Program in Rehabilitation Sciences, School of Physical Education, Physical Therapy and Occupational TherapyUniversidade Federal de Minas Gerais (UFMG)Belo HorizonteBrazil
  2. 2.Department of Physical TherapyUniversidade Federal de AlfenasAlfenasBrazil
  3. 3.Universidade Federal Do Vale Do Jequitinhonha E MucuriDiamantinaBrazil

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