Neurological impairment in a patient with concurrent cervical disc herniation and POEMS syndrome

  • Tingxian Ling
  • Limin Liu
  • Yueming Song
  • Shilian Zhou
  • Chunguang ZhouEmail author
Case Report



POEMS syndrome is a rare clonal plasma cell disease characterized by polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes. We report a rare case of neurological impairment in patients with concurrent cervical disc herniation and POEMS syndrome.


A patient presented to a local hospital with C3/4 and C4/5 disc herniation, apparent spinal cord compression concomitant with neurological signs, and concurrent POEMS syndrome. Anterior cervical discectomy and fusion was performed.


The limb numbness was only slightly alleviated, and 10 days postoperatively the patient complained of muscle weakness of the extremities and was referred to our hospital. The patients exhibited non-typical neurological signs and an enlarged liver and spleen that could not be explained. Electroneuromyography and immunofixation electrophoresis produced abnormal results. We diagnosed concurrent POEMS syndrome, for which drug therapy was prescribed. The patient’s symptoms receded.


Patients presenting with cervical spondylopathy and non-typical neurological signs and symptoms or other systemic problems should be evaluated for the presence of concurrent disease and ruled out differential diagnoses.


Neurological impairment POMES syndrome Cervical disc herniation Cervical spondylosis 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Tingxian Ling
    • 1
  • Limin Liu
    • 1
  • Yueming Song
    • 1
  • Shilian Zhou
    • 1
  • Chunguang Zhou
    • 1
    Email author
  1. 1.Department of OrthopedicsWest China Hospital of Sichuan UniversityChengduChina

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