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Contributions of birthweight, annualised weight gain and BMI to back pain in adults: a population-based co-twin control study of 2754 Australian twins

  • Hercules R. Leite
  • Amabile B. Dario
  • Alison R. Harmer
  • Vinicius C. Oliveira
  • Manuela L. Ferreira
  • Lucas Calais-Ferreira
  • Paulo H. Ferreira
Original Article

Abstract

Purpose

To investigate associations between anthropometric measures (birthweight, weight gain and current BMI) and back pain; and to determine whether these associations differ between those born with low or full birthweight.

Methods

The cross-sectional associations between the lifetime prevalence of back pain and anthropometric measures (birthweight, weight gain and current BMI) among 2754 adult twins were investigated in three stages: total sample; within-pair case–control for monozygotic and dizygotic twins together; and within-pair case–control analysis separated by dizygotic and monozygotic. Results were expressed as odds ratios (OR) and 95% confidence intervals (CI).

Results

Birthweight was not associated with back pain (OR 0.99; 95% CI 0.99–1.00), but a weak association was found between weight gain (OR 1.01; CI 1.00–1.01) or current BMI (OR 1.02; 95% CI 1.00–1.05) and back pain in the total sample analysis. These associations did not remain significant after adjusting for genetics. The associations did not differ between those whose were born with low or full birthweight.

Conclusion

Birthweight was not associated with prevalence of back pain in adulthood. Weight gain and current BMI were weakly associated with back pain prevalence in the total sample analysis but did not differ between those born with low or full birthweight. However, the small-magnitude association only just achieved significance and appeared to be confounded by genetics and the early shared environment. Our results suggest that a direct link between these predictors and back pain in adults is unlikely.

Graphical abstract

These slides can be retrieved under Electronic Supplementary Material.

Keywords

Birthweight BMI Twins Back pain Genetics 

Notes

Acknowledgements

HRL and LCF were supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Foundation, Ministry of Education, Brazil. MLF holds a National Health and Medical Research Council Research Fellowship and is a Sydney Medical Foundation Fellow. PHF is a National Health and Medical Research Council Fellow. This research was facilitated through access to Twins Research Australia, a national resource supported by a Centre of Research Excellence Grant (ID: 1079102), from the National Health and Medical Research Council, Australia.

Compliance with ethical standards

Conflict of interest

None.

Supplementary material

586_2018_5850_MOESM1_ESM.pptx (150 kb)
Supplementary material 1 (PPTX 150 kb)

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Hercules R. Leite
    • 1
    • 2
  • Amabile B. Dario
    • 2
  • Alison R. Harmer
    • 2
  • Vinicius C. Oliveira
    • 1
  • Manuela L. Ferreira
    • 3
  • Lucas Calais-Ferreira
    • 4
  • Paulo H. Ferreira
    • 2
  1. 1.Programa de Pós-Graduação em Reabilitação e Desempenho FuncionalUniversidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)DiamantinaBrazil
  2. 2.Musculoskeletal Health Research Group, Faculty of Health SciencesThe University of SydneyLidcombe, SydneyAustralia
  3. 3.Institute of Bone and Joint Research, The Kolling Institute, Sydney Medical SchoolThe University of SydneySydneyAustralia
  4. 4.Twins Research Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global HealthThe University of MelbourneMelbourneAustralia

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