European Spine Journal

, Volume 27, Issue 11, pp 2847–2853 | Cite as

The prevalence of chronic low back pain and lumbar deformities in patients with Parkinson’s disease: implications on spinal surgery

  • Imke GalazkyEmail author
  • Christina Caspari
  • Hans-Jochen Heinze
  • Joerg Franke
Original Article



This observational study was aimed at quantification of low back pain (LBP) in Parkinsonian patients and its morphological correlation.


Parkinson’s disease (PD) is a common disabling condition in the elderly population. Parkinsonian patients frequently are troubled by LBP. Causes for LBP in PD are muscular imbalances by the movement disorder itself and skeletal degeneration.


Ninety-seven PD patients and 97 controls were inquired about low back pain through the Oswestry Low Back Pain Disability Questionnaire and visual analogue scales. Fifty-four patients with LBP underwent X-ray of the lumbar spine in two planes and flexion–extension views. Parkinson’s disease was characterized by stage, disease duration, motor score, lateralization of symptoms and dosage of medication.


LBP occurred significantly more frequent in PD (87.6%) compared to controls (62.6%) with longer duration and higher pain intensity. Pain intensity and disability scores were associated with higher PD stages and higher motor scores. Patients with the hypokinetic PD subtype experienced more pain intensity. X-ray of the lumbar spine revealed lumbar arthrosis in 79.6%, scoliosis in 38.8% and spondylolisthesis in 24.1% of PD patients with LBP. Lateralization of scoliosis and PD symptoms were significantly correlated. Only a small portion of PD patients with LBP received specialized orthopaedic treatment.


LBP and lumbar degeneration are common in PD. Both are related to movement disorder symptoms. The knowledge about musculoskeletal conditions in Parkinson’s disease is important for an interdisciplinary conservative or operative treatment decision of LBP.

Graphical abstract

These slides can be retrieved under Electronic Supplementary Material.


Low back pain Lumbar degeneration Parkinson’s disease Adult spinal deformity 



Deep brain stimulation


Globus pallidus internus


Hoehn & Yahr stage


Low back pain


Levodopa equivalent daily dosage


Non-motor symptom


Oswestry Low Back Pain Disability Questionnaire


Parkinson’s disease


Other pain






Generally pain






Spinal cord stimulation


Subthalamic nucleus


Unified Parkinson’s disease rating scale, part III


Visual analogue scale


Compliance with ethical standards

Conflict of interest

The authors report no conflict of interest.

Supplementary material

586_2018_5748_MOESM1_ESM.pptx (267 kb)
Supplementary material 1 (PPTX 266 kb)
586_2018_5748_MOESM2_ESM.docx (25 kb)
An overview and time course of surgical interventions as well as infiltrations in the PD cohort. Abbreviations: ASD (adjacent segment disease), CT (computed tomography), H&Y (Hoehn & Yahr stage), L3, 4, 5 (lumbar segments 3, 4, 5), S1 (sacral segment 1), PD (Parkinson’s disease), PLIF (posterior lumbar interbody fusion), TLIF (transforaminal lumbar interbody fusion). (DOCX 26 kb)


  1. 1.
    Chaudhuri KR, Odin P, Antonini A, Martinez-Martin P (2011) Parkinson’s disease: the non-motor issues. Parkinsonism Relat Disord 17(10):717–723. CrossRefPubMedGoogle Scholar
  2. 2.
    Politis M, Wu K, Molloy S, G Bain P, Chaudhuri KR, Piccini P (2010) Parkinson’s disease symptoms: the patient’s perspective. Mov Disord Off J Mov Disord Soc 25(11):1646–1651. CrossRefGoogle Scholar
  3. 3.
    Ford B (1998) Pain in Parkinson’s disease. Clin Neurosci (New York, N.Y.) 5(2):63–72Google Scholar
  4. 4.
    Ashour R, Jankovic J (2006) Joint and skeletal deformities in Parkinson’s disease, multiple system atrophy, and progressive supranuclear palsy. Mov Disord Off J Mov Disord Soc 21(11):1856–1863. CrossRefGoogle Scholar
  5. 5.
    Kim YE, Lee W-W, Yun JY, Yang HJ, Kim H-J, Jeon BS (2013) Musculoskeletal problems in Parkinson’s disease: neglected issues. Parkinsonism Relat Disord 19(7):666–669. CrossRefPubMedGoogle Scholar
  6. 6.
    Etchepare F, Rozenberg S, Mirault T, Bonnet A-M, Lecorre C, Agid Y, Bourgeois P, Fautrel B (2006) Back problems in Parkinson’s disease: an underestimated problem. Jt Bone Spine revue du rhumatisme 73(3):298–302. CrossRefGoogle Scholar
  7. 7.
    Hallett M (2003) Parkinson revisited: pathophysiology of motor signs. Adv Neurol 91:19–28PubMedGoogle Scholar
  8. 8.
    McCormack HM, Horne DJ, Sheather S (1988) Clinical applications of visual analogue scales: a critical review. Psychol Med 18(4):1007–1019CrossRefGoogle Scholar
  9. 9.
    Fairbank JC, Couper J, Davies JB, O’Brien JP (1980) The Oswestry low back pain disability questionnaire. Physiotherapy 66(8):271–273PubMedGoogle Scholar
  10. 10.
    Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17(5):427–442CrossRefGoogle Scholar
  11. 11.
    Movement Disorder Society Task Force on Rating Scales for Parkinson's Disease (2003) The Unified Parkinson’s Disease Rating Scale (UPDRS): status and recommendations. Mov Disord Off J Mov Disord Soc 18(7):738–750.
  12. 12.
    Sandyk R (1982) Back pain as an early symptom of Parkinson’s disease. S Afr Med J Suid-Afrikaanse tydskrif vir geneeskunde 61(1):3PubMedGoogle Scholar
  13. 13.
    Broetz D, Eichner M, Gasser T, Weller M, Steinbach JP (2007) Radicular and nonradicular back pain in Parkinson’s disease: a controlled study. Mov Disord Off J Mov Disord Soc 22(6):853–856. CrossRefGoogle Scholar
  14. 14.
    Martin JP (1965) Curvature of the spine in post-encephalitic parkinsonism. J Neurol Neurosurg Psychiatry 28(5):395–400CrossRefGoogle Scholar
  15. 15.
    Herrera-Marschitz M, Utsumi H, Ungerstedt U (1990) Scoliosis in rats with experimentally-induced hemiparkinsonism: dependence upon striatal dopamine denervation. J Neurol Neurosurg Psychiatry 53(1):39–43CrossRefGoogle Scholar
  16. 16.
    Choi HJ, Smith JS, Shaffrey CI, Lafage VC, Schwab FJ, Ames CP, Matsumoto M, Baik JS, Ha Y (2015) Coronal plane spinal malalignment and Parkinson’s disease: prevalence and associations with disease severity. Spine J Off J N Am Spine Soc 15(1):115–121. CrossRefGoogle Scholar
  17. 17.
    Watanabe K, Hirano T, Katsumi K, Ohashi M, Ishikawa A, Koike R, Endo N, Nishizawa M, Shimohata T (2015) Characteristics and exacerbating factors of chronic low back pain in Parkinson’s disease. Int Orthop 39(12):2433–2438. CrossRefPubMedGoogle Scholar
  18. 18.
    Moon S-H, Lee H-M, Chun H-J, Kang K-T, Kim H-S, Park J-O, Moon E-S, Chong H-S, Sohn J-S, Kim H-J (2012) Surgical outcome of lumbar fusion surgery in patients with Parkinson disease. J Spinal Disord Tech 25(7):351–355. CrossRefPubMedGoogle Scholar
  19. 19.
    Babat LB, McLain RF, Bingaman W, Kalfas I, Young P, Rufo-Smith C (2004) Spinal surgery in patients with Parkinson’s disease: construct failure and progressive deformity. Spine 29(18):2006–2012CrossRefGoogle Scholar
  20. 20.
    Baker JF, McClelland S, Hart RA, Bess RS (2017) Management of spinal conditions in patients With Parkinson disease. J Am Acad Orthop Surg 25(8):e157–e165. CrossRefPubMedGoogle Scholar
  21. 21.
    Baker JF, McClelland S, Line BG, Smith JS, Hart RA, Ames CP, Shaffrey C, Bess S (2017) In-hospital complications and resource utilization following lumbar spine surgery in patients with Parkinson disease. Evaluation of the National Inpatient Sample Database. World Neurosurg 106:470–476. CrossRefPubMedGoogle Scholar
  22. 22.
    Schroeder JE, Hughes A, Sama A, Weinstein J, Kaplan L, Cammisa FP, Girardi FP (2015) Lumbar spine surgery in patients with Parkinson disease. J Bone Jt Surg 97(20):1661–1666. CrossRefGoogle Scholar
  23. 23.
    Rommel O, Wejwer D, Schybek K, Przybilski T, Jäger G, Gräber S, Berg D (2016) Lendenwirbelsäulenschmerzen bei Patienten mit Morbus Parkinson (Lumbar back pain in patients with Parkinson’s disease). Der Nervenarzt 87(4):418–425. CrossRefPubMedGoogle Scholar
  24. 24.
    Yamada K, Shinojima N, Hamasaki T, Kuratsu J-I (2016) Subthalamic nucleus stimulation improves Parkinson’s disease-associated camptocormia in parallel to its preoperative levodopa responsiveness. J Neurol Neurosurg Psychiatry 87(7):703–709. CrossRefPubMedGoogle Scholar
  25. 25.
    Schulz-Schaeffer WJ, Margraf NG, Munser S, Wrede A, Buhmann C, Deuschl G, Oehlwein C (2015) Effect of neurostimulation on camptocormia in Parkinson’s disease depends on symptom duration. Mov Disord Off J Mov Disord Soc 30(3):368–372. CrossRefGoogle Scholar
  26. 26.
    Srivanitchapoom P, Hallett M (2016) Camptocormia in Parkinson’s disease: definition, epidemiology, pathogenesis and treatment modalities. J Neurol Neurosurg Psychiatry 87(1):75–85. CrossRefPubMedGoogle Scholar
  27. 27.
    Margraf NG, Wrede A, Deuschl G, Schulz-Schaeffer WJ (2016) Pathophysiological concepts and treatment of camptocormia. J Parkinson’s Disease 6(3):485–501. CrossRefGoogle Scholar
  28. 28.
    Deuschl G, Schade-Brittinger C, Krack P, Volkmann J, Schäfer H, Bötzel K, Daniels C, Deutschländer A, Dillmann U, Eisner W, Gruber D, Hamel W, Herzog J, Hilker R, Klebe S, Kloss M, Koy J, Krause M, Kupsch A, Lorenz D, Lorenzl S, Mehdorn HM, Moringlane JR, Oertel W, Pinsker MO, Reichmann H, Reuss A, Schneider G-H, Schnitzler A, Steude U, Sturm V, Timmermann L, Tronnier V, Trottenberg T, Wojtecki L, Wolf E, Poewe W, Voges J (2006) A randomized trial of deep-brain stimulation for Parkinson’s disease. N Engl J Med 355(9):896–908. CrossRefPubMedGoogle Scholar
  29. 29.
    Jung YJ, Kim H-J, Jeon BS, Park H, Lee W-W, Paek SH (2015) An 8-year follow-up on the effect of subthalamic nucleus deep brain stimulation on pain in Parkinson disease. JAMA Neurol 72(5):504–510. CrossRefPubMedGoogle Scholar
  30. 30.
    Upadhyaya CD, Starr PA, Mummaneni PV (2010) Spinal deformity and Parkinson disease: a treatment algorithm. Neurosurg Focus 28(3):E5. CrossRefPubMedGoogle Scholar
  31. 31.
    Nishioka K, Nakajima M (2015) Beneficial therapeutic effects of spinal cord stimulation in advanced cases of Parkinson’s disease with intractable chronic pain: a case series. Neuromodulation J Int Neuromodulation Soc 18(8):751–753. CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Imke Galazky
    • 1
    Email author
  • Christina Caspari
    • 1
  • Hans-Jochen Heinze
    • 1
    • 2
    • 3
  • Joerg Franke
    • 4
  1. 1.Department of NeurologyOtto-von-Guericke UniversityMagdeburgGermany
  2. 2.German Centre for Neurodegenerative DiseasesOtto-von-Guericke UniversityMagdeburgGermany
  3. 3.Department of Behavioural NeurologyLeibniz Institute of NeurobiologyMagdeburgGermany
  4. 4.Department of OrthopaedicsKlinikum Magdeburg GmbHMagdeburgGermany

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