European Spine Journal

, Volume 21, Issue 12, pp 2407–2417 | Cite as

Recommendations for raloxifene use in daily clinical practice in the Swiss setting

  • Kurt Lippuner
  • P. A. Buchard
  • C. De Geyter
  • B. Imthurn
  • O. Lamy
  • M. Litschgi
  • F. Luzuy
  • K. Schiessl
  • P. Stute
  • M. Birkhäuser
Review Article

Abstract

Background/aim

Raloxifene is the first selective estrogen receptor modulator that has been approved for the treatment and prevention of osteoporosis in postmenopausal women in Europe and in the US. Although raloxifene reduces the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer, it is approved in that indication in the US but not in the EU. The aim was to characterize the clinical profiles of postmenopausal women expected to benefit most from therapy with raloxifene based on published scientific evidence to date.

Methods

Key individual patient characteristics relevant to the prescription of raloxifene in daily practice were defined by a board of Swiss experts in the fields of menopause and metabolic bone diseases and linked to published scientific evidence. Consensus was reached about translating these insights into daily practice.

Results

Through estrogen agonistic effects on bone, raloxifene reduces biochemical markers of bone turnover to premenopausal levels, increases bone mineral density (BMD) at the lumbar spine, proximal femur, and total body, and reduces vertebral fracture risk in women with osteopenia or osteoporosis with and without prevalent vertebral fracture. Through estrogen antagonistic effects on breast tissue, raloxifene reduces the risk of invasive estrogen-receptor positive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer. Finally, raloxifene increases the incidence of hot flushes, the risk of venous thromboembolic events, and the risk of fatal stroke in postmenopausal women at increased risk for coronary heart disease. Postmenopausal women in whom the use of raloxifene is considered can be categorized in a 2 × 2 matrix reflecting their bone status (osteopenic or osteoporotic based on their BMD T-score by dual energy X-ray absorptiometry) and their breast cancer risk (low or high based on the modified Gail model). Women at high risk of breast cancer should be considered for treatment with raloxifene.

Conclusion

Postmenopausal women between 50 and 70 years of age without climacteric symptoms with either osteopenia or osteoporosis should be evaluated with regard to their breast cancer risk and considered for treatment with raloxifene within the framework of its contraindications and precautions.

Keywords

Raloxifene Breast cancer Osteoporosis Fractures 

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Kurt Lippuner
    • 1
  • P. A. Buchard
    • 2
  • C. De Geyter
    • 3
  • B. Imthurn
    • 4
  • O. Lamy
    • 5
  • M. Litschgi
    • 6
  • F. Luzuy
    • 7
  • K. Schiessl
    • 4
  • P. Stute
    • 8
  • M. Birkhäuser
    • 9
  1. 1.Universitätspoliklinik für Osteoporose, Inselspital BernBernSwitzerland
  2. 2.Clinique romande de réadaptationSionSwitzerland
  3. 3.Klinik für Gynäkologische Endokrinologie und Reproduktionsmedizin, FrauenklinikUniversität BaselBaselSwitzerland
  4. 4.Klinik für Reproduktions–EndokrinologieUniversitätsspitalZurichSwitzerland
  5. 5.Service de Médecine Interne, Département de MédecineCHUVLausanneSwitzerland
  6. 6.Frauenklinik KantonsspitalSchaffhausenSwitzerland
  7. 7.Clinique des GrangettesGeneveSwitzerland
  8. 8.Abteilung für Gynäkologische Endokrinologie und ReproduktionsmedizinUniversitätsklinik für Frauenheilkunde, InselspitalBernSwitzerland
  9. 9.Schweiz. Vereinigung gegen die Osteoporose (SVGO/ASCO)BaselSwitzerland

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